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- W2068757674 abstract "Purpose of review To review the current knowledge on the clinical entity of metastasizing pleomorphic adenoma. Recent findings Using case studies, the literature continues to explore the potential to identify a chromosomal abnormality that might explain the clinical entity, and may constitute a submicroscopic malignant transformation with molecular genetic alterations. Presently there are no agreed histopathological p arameters that can identify or confirm a difference in behavior between the ‘common’ pleomorphic adenoma from the metastasizing pleomorphic adenoma. Summary The evidence supports that metastasizing pleomorphic adenoma is most likely to be an unrecognized and as yet unclassified malignant neoplasm and as such must be considered a low-grade, potentially lethal malignant disease when it presents, which may constitute a submicroscopic malignant transformation with molecular genetic alterations. Further research is required to answer the many questions." @default.
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- W2068757674 date "2005-04-01" @default.
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- W2068757674 title "???Metastasizing pleomorphic salivary adenoma??? should now be considered a low-grade malignancy with a lethal potential" @default.
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- W2068757674 doi "https://doi.org/10.1097/01.moo.0000153450.87288.2a" @default.
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