Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068758215> ?p ?o ?g. }
- W2068758215 endingPage "841" @default.
- W2068758215 startingPage "833" @default.
- W2068758215 abstract "Shigella flexneri, a Gram-negative bacillus belonging to the family Enterobacteriaceae, causes bacillary dysentery in humans by invading colonic epithelial cells. Processes by which epithelial cells, which are not professional phagocytes, may limit the spread of the invading microorganisms are poorly understood. This paper shows that IcsA (VirG), a 120kDa bacterial outer membrane protein responsible for intracellular and cell-to-cell spread through polymerization of actin, is a major substrate for phosphorylation by cyclic-dependent protein kinases. Site-directed mutagenesis of a sequence encoding phosphorylation consensus motif SSRRASS, located at residues 754–760, almost completely abolished the ability of this protein to be phosphorylated by protein kinase A. Such mutants expressed a ‘super Ics’ phenotype, characterized by an increased capacity to spread from cell-to-cell during the first three hours of infection in the HeLa cell infection assay. These data suggest that host-cell phosphorytation of key virulence proteins located on the bacterial surface may represent a significant host defence mechanism during the invasion process." @default.
- W2068758215 created "2016-06-24" @default.
- W2068758215 creator A5014406207 @default.
- W2068758215 creator A5069666784 @default.
- W2068758215 date "1992-04-01" @default.
- W2068758215 modified "2023-10-14" @default.
- W2068758215 title "Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intercellular spread of Shigella flexneri" @default.
- W2068758215 cites W1504748286 @default.
- W2068758215 cites W1526950041 @default.
- W2068758215 cites W1561125138 @default.
- W2068758215 cites W1738598303 @default.
- W2068758215 cites W1787690277 @default.
- W2068758215 cites W1844896946 @default.
- W2068758215 cites W1876016322 @default.
- W2068758215 cites W1892326398 @default.
- W2068758215 cites W1895994657 @default.
- W2068758215 cites W1899666652 @default.
- W2068758215 cites W1923742340 @default.
- W2068758215 cites W1938013375 @default.
- W2068758215 cites W1960007027 @default.
- W2068758215 cites W1967164846 @default.
- W2068758215 cites W1984640298 @default.
- W2068758215 cites W1988282769 @default.
- W2068758215 cites W1992195711 @default.
- W2068758215 cites W2008850485 @default.
- W2068758215 cites W2017733616 @default.
- W2068758215 cites W2028622989 @default.
- W2068758215 cites W2033846390 @default.
- W2068758215 cites W2034981642 @default.
- W2068758215 cites W2038449290 @default.
- W2068758215 cites W2038598410 @default.
- W2068758215 cites W2048674598 @default.
- W2068758215 cites W2049635421 @default.
- W2068758215 cites W2063450941 @default.
- W2068758215 cites W2070185967 @default.
- W2068758215 cites W2070555451 @default.
- W2068758215 cites W2071819661 @default.
- W2068758215 cites W2099144632 @default.
- W2068758215 cites W2100837269 @default.
- W2068758215 cites W2108465046 @default.
- W2068758215 cites W2111817213 @default.
- W2068758215 cites W2111820509 @default.
- W2068758215 cites W2117411464 @default.
- W2068758215 cites W2138270253 @default.
- W2068758215 cites W2154460798 @default.
- W2068758215 cites W2157387173 @default.
- W2068758215 cites W2334456031 @default.
- W2068758215 cites W2888511473 @default.
- W2068758215 doi "https://doi.org/10.1111/j.1365-2958.1992.tb01534.x" @default.
- W2068758215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1602963" @default.
- W2068758215 hasPublicationYear "1992" @default.
- W2068758215 type Work @default.
- W2068758215 sameAs 2068758215 @default.
- W2068758215 citedByCount "47" @default.
- W2068758215 countsByYear W20687582152012 @default.
- W2068758215 countsByYear W20687582152013 @default.
- W2068758215 countsByYear W20687582152014 @default.
- W2068758215 countsByYear W20687582152015 @default.
- W2068758215 countsByYear W20687582152016 @default.
- W2068758215 countsByYear W20687582152017 @default.
- W2068758215 countsByYear W20687582152020 @default.
- W2068758215 countsByYear W20687582152022 @default.
- W2068758215 crossrefType "journal-article" @default.
- W2068758215 hasAuthorship W2068758215A5014406207 @default.
- W2068758215 hasAuthorship W2068758215A5069666784 @default.
- W2068758215 hasConcept C104317684 @default.
- W2068758215 hasConcept C11960822 @default.
- W2068758215 hasConcept C146587185 @default.
- W2068758215 hasConcept C184235292 @default.
- W2068758215 hasConcept C2776986154 @default.
- W2068758215 hasConcept C2781217973 @default.
- W2068758215 hasConcept C547475151 @default.
- W2068758215 hasConcept C55493867 @default.
- W2068758215 hasConcept C60987743 @default.
- W2068758215 hasConcept C79879829 @default.
- W2068758215 hasConcept C86803240 @default.
- W2068758215 hasConcept C87325107 @default.
- W2068758215 hasConcept C89423630 @default.
- W2068758215 hasConcept C95444343 @default.
- W2068758215 hasConcept C97029542 @default.
- W2068758215 hasConceptScore W2068758215C104317684 @default.
- W2068758215 hasConceptScore W2068758215C11960822 @default.
- W2068758215 hasConceptScore W2068758215C146587185 @default.
- W2068758215 hasConceptScore W2068758215C184235292 @default.
- W2068758215 hasConceptScore W2068758215C2776986154 @default.
- W2068758215 hasConceptScore W2068758215C2781217973 @default.
- W2068758215 hasConceptScore W2068758215C547475151 @default.
- W2068758215 hasConceptScore W2068758215C55493867 @default.
- W2068758215 hasConceptScore W2068758215C60987743 @default.
- W2068758215 hasConceptScore W2068758215C79879829 @default.
- W2068758215 hasConceptScore W2068758215C86803240 @default.
- W2068758215 hasConceptScore W2068758215C87325107 @default.
- W2068758215 hasConceptScore W2068758215C89423630 @default.
- W2068758215 hasConceptScore W2068758215C95444343 @default.
- W2068758215 hasConceptScore W2068758215C97029542 @default.
- W2068758215 hasIssue "7" @default.
- W2068758215 hasLocation W20687582151 @default.
- W2068758215 hasLocation W20687582152 @default.