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- W2068758586 abstract "Oxidative stress has been involved in the pahtogenesis of different neurodegenerative diseases. Recently high levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG). a sensitive marker of DNA damage, were found in both nuclear and mitochondrial DNA of the brain in Alzheimer disease (AD). In this study we measured 8-OHdG in lymphocyte DNA obtained from AD patients and from agematched controls. The high levels of 8-OHdG found in the lymphocytes of AD patients support the hypothesis that a general imbalance is present in this disease between oxidants and antioxidants." @default.
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- W2068758586 date "1998-01-01" @default.
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- W2068758586 title "Oxidative stress and lymphocytes in Alzheimer disease" @default.
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- W2068758586 doi "https://doi.org/10.1016/s0167-4943(98)80044-7" @default.
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