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- W2068759863 abstract "Objective: To evaluate the responsiveness of children with juvenile idiopathic arthritis ( JIA) to pneumococcal vaccine and to determine whether the response was influenced by disease subtype and immunosuppressive treatment. Methods: 50 patients with JIA (all in remission) and 24 healthy children were included in the study. All children were vaccinated with 23-valent pneumococcal vaccine. Serum samples were collected from each child at the beginning and six weeks after the vaccination in order to determine anti-pneumococcal capsular polysaccharide (PCP) IgG levels by ELISA. A two-fold or more rises in antibody titer after the vaccination was considered as positive immune response. Results: Six weeks after the vaccination 46 (92%) children with JIA and 23 (95.8%) healthy children developed an effective antibody response. This vaccine responsiveness was not different between two groups (p=0.34). The anti-PCP IgG levels of healthy children were significantly higher than anti-PCP IgG levels of children with JIA at the beginning and after the vaccination (p=0.004 and p=0.029). Conclusion: Children with JIA had an adequate response to pneumococcal vaccine and the response was influenced by MTX and prednisone treatment. The vaccine should be undertaken during the time period when the child receiving the smallest possible dose of the immunosuppressive therapy." @default.
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- W2068759863 date "2012-01-01" @default.
- W2068759863 modified "2023-09-27" @default.
- W2068759863 title "Pneumococcal Vaccination in Juvenile Idiopathic Arthritis" @default.
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- W2068759863 doi "https://doi.org/10.5455/apr.010720120028" @default.
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