Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068759951> ?p ?o ?g. }
- W2068759951 endingPage "307" @default.
- W2068759951 startingPage "301" @default.
- W2068759951 abstract "The hypothalamo–pituitary–adrenal (HPA) axis is involved in stress, depression and anxiety. Controversy exists on HPA axis activation during panic attacks (PAs). We examined whether the HPA axis is involved in the escape or panic-like response in an animal model of PAs induced by electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats. Additionally, rats were also treated with chronic administration of buspirone (BUSP) and escitalopram (ESCIT), respectively; and they were stimulated in the open-field arena for panic-like reaction. Levels of stress hormone corticosterone were measured following 30 min after escape or panic condition. Our results demonstrated that the levels of plasma corticosterone were significantly increased after the induction of escape or panic-like response in comparison with the sham animals. The levels of corticosterone were significantly decreased in the dlPAG stimulated groups after rats were treated chronically with the ESCIT but not the BUSP as compared to the saline treated animals. Importantly, the increase of corticosterone level after escape or panic-like response was paralleled by an increase of neuronal activation of c-Fos in both the parvocellular and magnocellular paraventricular nucleus of the hypothalamus. Moreover, the c-Fos data also showed a decrease in the number of positive cells particularly for the ESCIT as well as the BUSP in comparison with the saline stimulated animals. In conclusion, the present study clearly demonstrated that PA or escape response activates the HPA axis and it remains difficult to anticipate the mechanism underlying HPA axis during PAs and its relationship with 5-HT drugs." @default.
- W2068759951 created "2016-06-24" @default.
- W2068759951 creator A5001421653 @default.
- W2068759951 creator A5004432345 @default.
- W2068759951 creator A5005468329 @default.
- W2068759951 creator A5007362708 @default.
- W2068759951 creator A5016027203 @default.
- W2068759951 creator A5021877663 @default.
- W2068759951 creator A5052502996 @default.
- W2068759951 creator A5059324771 @default.
- W2068759951 creator A5062092154 @default.
- W2068759951 creator A5071341503 @default.
- W2068759951 creator A5082487583 @default.
- W2068759951 creator A5088067171 @default.
- W2068759951 date "2011-04-01" @default.
- W2068759951 modified "2023-10-12" @default.
- W2068759951 title "Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in rats" @default.
- W2068759951 cites W1519701208 @default.
- W2068759951 cites W172797153 @default.
- W2068759951 cites W1966317259 @default.
- W2068759951 cites W1976372731 @default.
- W2068759951 cites W1977599131 @default.
- W2068759951 cites W1978136174 @default.
- W2068759951 cites W1982852718 @default.
- W2068759951 cites W1983437608 @default.
- W2068759951 cites W1985367308 @default.
- W2068759951 cites W1986811275 @default.
- W2068759951 cites W1986881967 @default.
- W2068759951 cites W1990830377 @default.
- W2068759951 cites W1991628876 @default.
- W2068759951 cites W1994092198 @default.
- W2068759951 cites W1994920775 @default.
- W2068759951 cites W1995792901 @default.
- W2068759951 cites W2005862509 @default.
- W2068759951 cites W2006864110 @default.
- W2068759951 cites W2007729882 @default.
- W2068759951 cites W2008275354 @default.
- W2068759951 cites W2010923944 @default.
- W2068759951 cites W2016285975 @default.
- W2068759951 cites W2016826032 @default.
- W2068759951 cites W2019766664 @default.
- W2068759951 cites W2029388221 @default.
- W2068759951 cites W2029904551 @default.
- W2068759951 cites W2030703484 @default.
- W2068759951 cites W2034359560 @default.
- W2068759951 cites W2041255525 @default.
- W2068759951 cites W2046882018 @default.
- W2068759951 cites W2048555560 @default.
- W2068759951 cites W2056402432 @default.
- W2068759951 cites W2065700655 @default.
- W2068759951 cites W2068373737 @default.
- W2068759951 cites W2068555985 @default.
- W2068759951 cites W2070770543 @default.
- W2068759951 cites W2071094983 @default.
- W2068759951 cites W2071470866 @default.
- W2068759951 cites W2074589903 @default.
- W2068759951 cites W2079221966 @default.
- W2068759951 cites W2081567401 @default.
- W2068759951 cites W2082091099 @default.
- W2068759951 cites W2082113957 @default.
- W2068759951 cites W2085006035 @default.
- W2068759951 cites W2085839022 @default.
- W2068759951 cites W2090878720 @default.
- W2068759951 cites W2093670138 @default.
- W2068759951 cites W2093934115 @default.
- W2068759951 cites W2093940979 @default.
- W2068759951 cites W2095348755 @default.
- W2068759951 cites W2095363339 @default.
- W2068759951 cites W2099845285 @default.
- W2068759951 cites W2110115314 @default.
- W2068759951 cites W2116629441 @default.
- W2068759951 cites W2123752945 @default.
- W2068759951 cites W2134468050 @default.
- W2068759951 cites W2135884966 @default.
- W2068759951 cites W2137082982 @default.
- W2068759951 cites W2140176228 @default.
- W2068759951 cites W2150290582 @default.
- W2068759951 cites W2158736364 @default.
- W2068759951 cites W2165436113 @default.
- W2068759951 cites W2167576033 @default.
- W2068759951 cites W2324482687 @default.
- W2068759951 cites W2883849285 @default.
- W2068759951 cites W4211156221 @default.
- W2068759951 cites W4247086564 @default.
- W2068759951 doi "https://doi.org/10.1016/j.bbr.2010.12.026" @default.
- W2068759951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21185871" @default.
- W2068759951 hasPublicationYear "2011" @default.
- W2068759951 type Work @default.
- W2068759951 sameAs 2068759951 @default.
- W2068759951 citedByCount "25" @default.
- W2068759951 countsByYear W20687599512012 @default.
- W2068759951 countsByYear W20687599512013 @default.
- W2068759951 countsByYear W20687599512014 @default.
- W2068759951 countsByYear W20687599512015 @default.
- W2068759951 countsByYear W20687599512016 @default.
- W2068759951 countsByYear W20687599512017 @default.
- W2068759951 countsByYear W20687599512019 @default.
- W2068759951 countsByYear W20687599512020 @default.