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• W2068759952 abstract "Objective To determine the effects of tibolone or oestradiol (E2)/norethisterone acetate (NETA) hormone replacement therapy on glucose and insulin metabolism in postmenopausal women. Design Single-centre double-blind placebo-controlled randomized clinical trial. Subjects/Methods We randomized 105 healthy postmenopausal women to tibolone 2·5 mg daily, continuous combined oral E2 2 mg/NETA 1 mg daily or placebo over a 2-year study. We performed intravenous glucose tolerance tests (IVGTT) with measurements of plasma glucose, insulin and C-peptide concentrations and the IVGTT glucose elimination rate, k. Mathematical modelling was performed to determine measures of insulin sensitivity, Si, pancreatic insulin secretion and hepatic and plasma insulin elimination. Results Tibolone decreased Si to 53–63% and k to 72–79% of baseline values but increased IVGTT phase 2 C-peptide concentrations 1·6–1·8-fold and pancreatic insulin secretion 2·2–2·4-fold, so overall IVGTT glucose concentrations were unaffected. Similar, but for k, significantly smaller changes in insulin and C-peptide secretion were seen with E2/NETA, also with no effect on overall IVGTT glucose concentrations. Conclusions Tibolone reduces insulin sensitivity. Healthy postmenopausal women seem able to compensate for this and maintain normal postload glucose concentrations, but it may not be advisable to prescribe tibolone to women with, or at increased risk for, diabetes." @default.
• W2068759952 created "2016-06-24" @default.
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• W2068759952 date "2013-01-07" @default.
• W2068759952 modified "2023-09-23" @default.
• W2068759952 title "Effects of tibolone or continuous combined oestradiol/norethisterone acetate on glucose and insulin metabolism" @default.
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• W2068759952 doi "https://doi.org/10.1111/j.1365-2265.2012.04491.x" @default.
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