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• W2068763775 abstract "We report high expression of the maternally imprinted gene PEG10 in high-risk B-CLL defined by high LPL mRNA expression. Differential expression was initially identified by microarray analysis and confirmed by real time PCR in 42 B-CLL patients. mRNA expression ranged from 0.3- to 375.4-fold compared to normal peripheral blood mononuclear cells (PBMNC). Expression levels in CD19+ B-CLL cells were 100-fold higher than in B-cells from healthy donors. PEG10 expression levels in B-CLL patient samples remained stable over time even after chemotherapy. High PEG10 expression correlated with high LPL expression (p = 0.001) and a positive Coombs' test (p = 0.04). Interestingly, similar expression patterns were observed for the neighbouring imprinted gene sarcoglycan-ε (SGCE). Monoallelic expression and maintained imprinting of PEG10 were found by allele- or methylation-specific PCR. The intensity of intracellular staining of PEG10 protein corresponded to mRNA levels as confirmed by immunofluorescence staining. Short term knock-down of PEG10 in B-CLL cells and HepG2 cells was not associated with changes in cell survival but resulted in a significant change in the expression of 80 genes. However, long term inhibition of PEG10 led to induction of apoptosis in B-CLL cells. Our data indicate (i) a prognostic value of PEG10 in B-CLL patients; (ii) specific deregulation of the imprinted locus at 7q21 in high-risk B-CLL; (iii) a potential functional and biological role of PEG10 protein expression. Altogether, PEG10 represents a novel marker in B-CLL. © 2007 Wiley-Liss, Inc." @default.
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• W2068763775 date "2007-07-09" @default.
• W2068763775 modified "2023-10-13" @default.
• W2068763775 title "Overexpression of the paternally expressed gene <i>10 (PEG10)</i> from the imprinted locus on chromosome 7q21 in high‐risk B‐cell chronic lymphocytic leukemia" @default.
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• W2068763775 doi "https://doi.org/10.1002/ijc.22929" @default.
• W2068763775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17621626" @default.
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