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• W2068763844 abstract "Completion of the Drosophila genome has enabled the use of proteomic approaches for studying complex processes such as the innate immune defense against microorganisms. Microbial infection leads to the activation of responses involving changes at translational and post-translational levels. Proteomics is a tool for assessing such changes in protein expression, localization and post-translational modification. Recently, several studies have reported whole-genome analyses of the Drosophila immune response, both at the transcriptome and proteome levels, leading to a more comprehensive view of fly immunity. In this review, we describe and compare the proteomic techniques used in these analyses and discuss the results obtained by differential protein profiling of the Drosophila immune response. Completion of the Drosophila genome has enabled the use of proteomic approaches for studying complex processes such as the innate immune defense against microorganisms. Microbial infection leads to the activation of responses involving changes at translational and post-translational levels. Proteomics is a tool for assessing such changes in protein expression, localization and post-translational modification. Recently, several studies have reported whole-genome analyses of the Drosophila immune response, both at the transcriptome and proteome levels, leading to a more comprehensive view of fly immunity. In this review, we describe and compare the proteomic techniques used in these analyses and discuss the results obtained by differential protein profiling of the Drosophila immune response. the set of all expressed mRNA in a cell, tissue or organ. the set of all expressed proteins in a cell, tissue or organism. the set of all secreted proteins. the large-scale screening and documentation of proteins in biological samples and the method for investigating how proteins are expressed, regulated and modified in living systems. two-dimensional gel electrophoresis is a powerful method for resolving complex protein mixtures on the basic of their isoelectric points by isoelectric focusing in the first dimension and according to size or mass by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the second dimension. two-dimensional differential gel electrophoresis is used for the simultaneous analysis of control and treated samples. The samples are labeled with two spectrally resolvable fluorescent dyes, such as propyl-Cy3 and methyl-Cy5, mixed, separated in a single 2D gel and detected at two different excitation and emission wavelengths. Alternatively, stable isotopes can be used for differential labeling of the control and treated samples. matrix-assisted laser desorption ionization time-of-flight mass spectrometry is used to determine the exact mass of peptides or proteins. Coupled liquid chromatography and tandem mass spectrometry is used for direct analysis of a complex protein mixture without the 2-DE step." @default.
• W2068763844 created "2016-06-24" @default.
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• W2068763844 date "2004-11-01" @default.
• W2068763844 modified "2023-10-14" @default.
• W2068763844 title "Proteomics of the Drosophila immune response" @default.
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• W2068763844 doi "https://doi.org/10.1016/j.tibtech.2004.09.002" @default.
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