Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068765556> ?p ?o ?g. }
- W2068765556 endingPage "782" @default.
- W2068765556 startingPage "772" @default.
- W2068765556 abstract "Epilepsy surgery is an accepted treatment option in patients with medically refractory focal epilepsy. Despite various advances in recording and localization noninvasive and invasive techniques (including electroencephalography (EEG), magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetoencephalography (MEG), subdural grids, depth electrodes, and so on), the seizure outcome following surgical resection remains suboptimal in a significant number of patients. The availability of long-term outcome data on an increasing number of patients suggests two major temporal patterns of seizure recurrence (early vs. late) that implicate the following two different mechanisms for seizure recurrence: (1) a failure to either define/resect the epileptogenic zone, and (2) the nonstatic nature of epilepsy as a disease through the persistence of proepileptic cortical pathology. We describe the temporal patterns of epilepsy surgery failures and discuss their potential clinical, histopathologic, genetic, and molecular mechanisms. In addition, we review predictors of successful surgical interventions and analyze the natural history of epilepsy following surgical intervention. We hypothesize that the acute/early postoperative failures are due to errors in localizing and/or resecting the epileptic focus, whereas late recurrences are likely due to development/maturation of a new and active epileptic focus (de novo epileptogenesis)." @default.
- W2068765556 created "2016-06-24" @default.
- W2068765556 creator A5013584913 @default.
- W2068765556 creator A5018120847 @default.
- W2068765556 creator A5030079496 @default.
- W2068765556 creator A5036239459 @default.
- W2068765556 creator A5074026372 @default.
- W2068765556 creator A5078408270 @default.
- W2068765556 date "2013-04-15" @default.
- W2068765556 modified "2023-10-04" @default.
- W2068765556 title "Temporal patterns and mechanisms of epilepsy surgery failure" @default.
- W2068765556 cites W1509919822 @default.
- W2068765556 cites W1528314503 @default.
- W2068765556 cites W1536932073 @default.
- W2068765556 cites W1590403484 @default.
- W2068765556 cites W1708052843 @default.
- W2068765556 cites W1737252742 @default.
- W2068765556 cites W1797398591 @default.
- W2068765556 cites W1871191509 @default.
- W2068765556 cites W1901847463 @default.
- W2068765556 cites W1919268706 @default.
- W2068765556 cites W1928622425 @default.
- W2068765556 cites W1942214786 @default.
- W2068765556 cites W1967476276 @default.
- W2068765556 cites W1968775776 @default.
- W2068765556 cites W1972962459 @default.
- W2068765556 cites W1973945160 @default.
- W2068765556 cites W1975077266 @default.
- W2068765556 cites W1976384042 @default.
- W2068765556 cites W1984684625 @default.
- W2068765556 cites W1988280863 @default.
- W2068765556 cites W1990576650 @default.
- W2068765556 cites W1995425017 @default.
- W2068765556 cites W1997765570 @default.
- W2068765556 cites W1998171204 @default.
- W2068765556 cites W1998794491 @default.
- W2068765556 cites W2001078546 @default.
- W2068765556 cites W2001660018 @default.
- W2068765556 cites W2003171800 @default.
- W2068765556 cites W2008934361 @default.
- W2068765556 cites W2013385033 @default.
- W2068765556 cites W2016888695 @default.
- W2068765556 cites W2020576928 @default.
- W2068765556 cites W2020694473 @default.
- W2068765556 cites W2022521916 @default.
- W2068765556 cites W2023043635 @default.
- W2068765556 cites W2024824899 @default.
- W2068765556 cites W2027970152 @default.
- W2068765556 cites W2031650032 @default.
- W2068765556 cites W2032763785 @default.
- W2068765556 cites W2036183924 @default.
- W2068765556 cites W2038351704 @default.
- W2068765556 cites W2041398126 @default.
- W2068765556 cites W2042654979 @default.
- W2068765556 cites W2043089444 @default.
- W2068765556 cites W2043254225 @default.
- W2068765556 cites W2045693643 @default.
- W2068765556 cites W2047540883 @default.
- W2068765556 cites W2048544667 @default.
- W2068765556 cites W2048605757 @default.
- W2068765556 cites W2054045257 @default.
- W2068765556 cites W2054083058 @default.
- W2068765556 cites W2055946462 @default.
- W2068765556 cites W2060146172 @default.
- W2068765556 cites W2060885699 @default.
- W2068765556 cites W2064757905 @default.
- W2068765556 cites W2065040962 @default.
- W2068765556 cites W2065901109 @default.
- W2068765556 cites W2069133581 @default.
- W2068765556 cites W2069456915 @default.
- W2068765556 cites W2072825320 @default.
- W2068765556 cites W2074558629 @default.
- W2068765556 cites W2077743396 @default.
- W2068765556 cites W2085665206 @default.
- W2068765556 cites W2086833393 @default.
- W2068765556 cites W2090989662 @default.
- W2068765556 cites W2093247684 @default.
- W2068765556 cites W2093757039 @default.
- W2068765556 cites W2094268230 @default.
- W2068765556 cites W2097829237 @default.
- W2068765556 cites W2107974789 @default.
- W2068765556 cites W2109598930 @default.
- W2068765556 cites W2120465381 @default.
- W2068765556 cites W2120509234 @default.
- W2068765556 cites W2122247828 @default.
- W2068765556 cites W2126727507 @default.
- W2068765556 cites W2129146124 @default.
- W2068765556 cites W2131399091 @default.
- W2068765556 cites W2131979832 @default.
- W2068765556 cites W2133396632 @default.
- W2068765556 cites W2133555827 @default.
- W2068765556 cites W2134705006 @default.
- W2068765556 cites W2156442977 @default.
- W2068765556 cites W2158294440 @default.
- W2068765556 cites W2163663463 @default.
- W2068765556 cites W2167922107 @default.
- W2068765556 cites W2169705862 @default.
- W2068765556 cites W2317082283 @default.