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- W2068768108 abstract "Forodesine HCl is a potent inhibitor of the enzyme purine nucleoside phosphorylase (PNP) and is currently in clinical trials for the treatment of leukemia and lymphoma. Animal models indicated that forodesine HCl would have low oral bioavailability in humans and it was initially developed as an intravenous formulation. We were interested in identifying analogs of forodesine HCl with improved oral bioavailability. The 2′-deoxy analog (BCX-3040) was synthesized and its pharmacokinetic and pharmacodynamic properties compared with forodesine HCl." @default.
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- W2068768108 date "2005-09-01" @default.
- W2068768108 modified "2023-10-16" @default.
- W2068768108 title "Synthesis and Pharmacokinetic and Pharmacodynamic Evaluation of the Forodesine HCl Analog BCX-3040" @default.
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- W2068768108 doi "https://doi.org/10.1080/15257770500267246" @default.
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