FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068769918> ?p ?o ?g. }

• W2068769918 endingPage "4785" @default.
• W2068769918 startingPage "4778" @default.
• W2068769918 abstract "A single base change in the helicase superfamily 1 domain of the yeast Saccharomyces cerevisiae SEN1 gene results in a heat-sensitive mutation that alters the cellular abundance of many RNA species. We compared the relative amounts of RNAs between cells that are wild-type and mutant after temperature-shift. In the mutant several RNAs were found to either decrease or increase in abundance. The affected RNAs include tRNAs, rRNAs and small nuclear and nucleolar RNAs. Many of the affected RNAs have been positively identified and include end-matured precursor tRNAs and the small nuclear and nucleolar RNAs U5 and snR40 and snR45. Several small nucleolar RNAs co-immunoprecipitate with Sen1 but differentially associate with the wild-type and mutant protein. Its inactivation also impairs precursor rRNA maturation, resulting in increased accumulation of 35S and 6S precursor rRNAs and reduced levels of 20S, 23S and 27S rRNA processing intermediates. Thus, Sen1 is required for the biosynthesis of various functionally distinct classes of nuclear RNAs. We propose that Sen1 is an RNA helicase acting on a wide range of RNA classes. Its effects on the targeted RNAs in turn enable ribonuclease activity." @default.
• W2068769918 created "2016-06-24" @default.
• W2068769918 creator A5000000400 @default.
• W2068769918 creator A5002712072 @default.
• W2068769918 creator A5008328071 @default.
• W2068769918 creator A5029795537 @default.
• W2068769918 creator A5081892369 @default.
• W2068769918 date "1997-12-01" @default.
• W2068769918 modified "2023-09-27" @default.
• W2068769918 title "The yeast SEN1 gene is required for the processing of diverse RNA classes" @default.
• W2068769918 cites W1483737232 @default.
• W2068769918 cites W1496392745 @default.
• W2068769918 cites W1546922418 @default.
• W2068769918 cites W1583965246 @default.
• W2068769918 cites W176510002 @default.
• W2068769918 cites W1779286822 @default.
• W2068769918 cites W1914127277 @default.
• W2068769918 cites W1917364401 @default.
• W2068769918 cites W1925704498 @default.
• W2068769918 cites W1927660041 @default.
• W2068769918 cites W1929480046 @default.
• W2068769918 cites W1965401154 @default.
• W2068769918 cites W1967356824 @default.
• W2068769918 cites W1968832089 @default.
• W2068769918 cites W1969677285 @default.
• W2068769918 cites W1969737313 @default.
• W2068769918 cites W1971009251 @default.
• W2068769918 cites W1972544982 @default.
• W2068769918 cites W1972619373 @default.
• W2068769918 cites W1976019826 @default.
• W2068769918 cites W1979131591 @default.
• W2068769918 cites W1979572236 @default.
• W2068769918 cites W1988222904 @default.
• W2068769918 cites W1988479344 @default.
• W2068769918 cites W1997017839 @default.
• W2068769918 cites W2005447120 @default.
• W2068769918 cites W2012288774 @default.
• W2068769918 cites W2017688328 @default.
• W2068769918 cites W2027078124 @default.
• W2068769918 cites W2048620082 @default.
• W2068769918 cites W2049050286 @default.
• W2068769918 cites W2061754995 @default.
• W2068769918 cites W2066886643 @default.
• W2068769918 cites W2068565185 @default.
• W2068769918 cites W2069344759 @default.
• W2068769918 cites W2072174598 @default.
• W2068769918 cites W2073477072 @default.
• W2068769918 cites W2075736819 @default.
• W2068769918 cites W2081283384 @default.
• W2068769918 cites W2086779374 @default.
• W2068769918 cites W2095321031 @default.
• W2068769918 cites W2097343134 @default.
• W2068769918 cites W2099158977 @default.
• W2068769918 cites W2100269820 @default.
• W2068769918 cites W2103699284 @default.
• W2068769918 cites W2105377891 @default.
• W2068769918 cites W2106755835 @default.
• W2068769918 cites W2111978918 @default.
• W2068769918 cites W2114991027 @default.
• W2068769918 cites W2126038080 @default.
• W2068769918 cites W2128398569 @default.
• W2068769918 cites W2134201576 @default.
• W2068769918 cites W2135493103 @default.
• W2068769918 cites W2142181044 @default.
• W2068769918 cites W2143240659 @default.
• W2068769918 cites W2146140904 @default.
• W2068769918 cites W2147490315 @default.
• W2068769918 cites W2148328615 @default.
• W2068769918 cites W2151879743 @default.
• W2068769918 cites W2154010734 @default.
• W2068769918 cites W2171372991 @default.
• W2068769918 cites W21943246 @default.
• W2068769918 cites W280171630 @default.
• W2068769918 doi "https://doi.org/10.1093/nar/25.23.4778" @default.
• W2068769918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/147120" @default.
• W2068769918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9365256" @default.
• W2068769918 hasPublicationYear "1997" @default.
• W2068769918 type Work @default.
• W2068769918 sameAs 2068769918 @default.
• W2068769918 citedByCount "103" @default.
• W2068769918 countsByYear W20687699182012 @default.
• W2068769918 countsByYear W20687699182013 @default.
• W2068769918 countsByYear W20687699182014 @default.
• W2068769918 countsByYear W20687699182015 @default.
• W2068769918 countsByYear W20687699182016 @default.
• W2068769918 countsByYear W20687699182017 @default.
• W2068769918 countsByYear W20687699182018 @default.
• W2068769918 countsByYear W20687699182019 @default.
• W2068769918 countsByYear W20687699182020 @default.
• W2068769918 countsByYear W20687699182021 @default.
• W2068769918 countsByYear W20687699182022 @default.
• W2068769918 countsByYear W20687699182023 @default.
• W2068769918 crossrefType "journal-article" @default.
• W2068769918 hasAuthorship W2068769918A5000000400 @default.
• W2068769918 hasAuthorship W2068769918A5002712072 @default.
• W2068769918 hasAuthorship W2068769918A5008328071 @default.
• W2068769918 hasAuthorship W2068769918A5029795537 @default.
• W2068769918 hasAuthorship W2068769918A5081892369 @default.

• next