Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068775057> ?p ?o ?g. }
- W2068775057 endingPage "1123" @default.
- W2068775057 startingPage "1105" @default.
- W2068775057 abstract "The lack of appropriate human cardiomyocyte-based experimental platform has largely hindered the study of cardiac diseases and the development of therapeutic strategies. To date, somatic cells isolated from human subjects can be reprogramed into induced pluripotent stem cells (iPSCs) and subsequently differentiated into functional cardiomyocytes. This powerful reprogramming technology provides a novel in vitro human cell-based platform for the study of human hereditary cardiac disorders. The clinical potential of using iPSCs derived from patients with inherited cardiac disorders for therapeutic studies have been increasingly highlighted. In this review, the standard procedures for generating patient-specific iPSCs and the latest commonly used cardiac differentiation protocols will be outlined. Furthermore, the progress and limitations of current applications of iPSCs and iPSCs-derived cardiomyocytes in cell replacement therapy, disease modeling, drug-testing and toxicology studies will be discussed in detail." @default.
- W2068775057 created "2016-06-24" @default.
- W2068775057 creator A5007223142 @default.
- W2068775057 creator A5031259698 @default.
- W2068775057 creator A5065770366 @default.
- W2068775057 date "2014-10-15" @default.
- W2068775057 modified "2023-10-14" @default.
- W2068775057 title "Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells" @default.
- W2068775057 cites W180287309 @default.
- W2068775057 cites W1895993106 @default.
- W2068775057 cites W1966127544 @default.
- W2068775057 cites W1967753406 @default.
- W2068775057 cites W1972774086 @default.
- W2068775057 cites W1973063329 @default.
- W2068775057 cites W1973856678 @default.
- W2068775057 cites W1977025496 @default.
- W2068775057 cites W1978173381 @default.
- W2068775057 cites W1978953141 @default.
- W2068775057 cites W1981531825 @default.
- W2068775057 cites W1988290340 @default.
- W2068775057 cites W1988373211 @default.
- W2068775057 cites W1993138656 @default.
- W2068775057 cites W1995362282 @default.
- W2068775057 cites W1995864831 @default.
- W2068775057 cites W1996439106 @default.
- W2068775057 cites W1999148174 @default.
- W2068775057 cites W2003969343 @default.
- W2068775057 cites W2007699535 @default.
- W2068775057 cites W2010417854 @default.
- W2068775057 cites W2010475088 @default.
- W2068775057 cites W2010743526 @default.
- W2068775057 cites W2019074198 @default.
- W2068775057 cites W2019166705 @default.
- W2068775057 cites W2025076186 @default.
- W2068775057 cites W2026404421 @default.
- W2068775057 cites W2027833338 @default.
- W2068775057 cites W2030290211 @default.
- W2068775057 cites W2036700841 @default.
- W2068775057 cites W2038815755 @default.
- W2068775057 cites W2041410896 @default.
- W2068775057 cites W2047036934 @default.
- W2068775057 cites W2057589832 @default.
- W2068775057 cites W2061792807 @default.
- W2068775057 cites W2070769557 @default.
- W2068775057 cites W2075339313 @default.
- W2068775057 cites W2081524260 @default.
- W2068775057 cites W2082135380 @default.
- W2068775057 cites W2083599207 @default.
- W2068775057 cites W2084172388 @default.
- W2068775057 cites W2084540645 @default.
- W2068775057 cites W2088152986 @default.
- W2068775057 cites W2090820454 @default.
- W2068775057 cites W2094140022 @default.
- W2068775057 cites W2100242048 @default.
- W2068775057 cites W2100561528 @default.
- W2068775057 cites W2101986300 @default.
- W2068775057 cites W2104790299 @default.
- W2068775057 cites W2104996733 @default.
- W2068775057 cites W2106379660 @default.
- W2068775057 cites W2106854002 @default.
- W2068775057 cites W2108903695 @default.
- W2068775057 cites W2111619469 @default.
- W2068775057 cites W2113098823 @default.
- W2068775057 cites W2113927644 @default.
- W2068775057 cites W2114438447 @default.
- W2068775057 cites W2115644752 @default.
- W2068775057 cites W2116351152 @default.
- W2068775057 cites W2119653736 @default.
- W2068775057 cites W2120498003 @default.
- W2068775057 cites W2123240976 @default.
- W2068775057 cites W2125199827 @default.
- W2068775057 cites W2125987139 @default.
- W2068775057 cites W2126877193 @default.
- W2068775057 cites W2128923693 @default.
- W2068775057 cites W2129115366 @default.
- W2068775057 cites W2138412157 @default.
- W2068775057 cites W2138773108 @default.
- W2068775057 cites W2138977668 @default.
- W2068775057 cites W2142046859 @default.
- W2068775057 cites W2151609026 @default.
- W2068775057 cites W2152635048 @default.
- W2068775057 cites W2153156044 @default.
- W2068775057 cites W2155235762 @default.
- W2068775057 cites W2164641172 @default.
- W2068775057 cites W2165179483 @default.
- W2068775057 cites W2165781160 @default.
- W2068775057 cites W2166305181 @default.
- W2068775057 cites W2167874626 @default.
- W2068775057 cites W2169859308 @default.
- W2068775057 cites W2410439417 @default.
- W2068775057 cites W3021289375 @default.
- W2068775057 cites W65492296 @default.
- W2068775057 cites W78593386 @default.
- W2068775057 doi "https://doi.org/10.3390/jcm3041105" @default.
- W2068775057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4470173" @default.
- W2068775057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26237594" @default.
- W2068775057 hasPublicationYear "2014" @default.
- W2068775057 type Work @default.