Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068777742> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2068777742 abstract "Systemic inflammation has been associated with adverse effects on cognition and brain structure, and may accelerate neurodegenerative disease processes; however, it is less clear whether changes in inflammation are associated with brain structure. We studied 276 black and white older adults (mean age=83 years at time of imaging) enrolled in a prospective study of aging (Health ABC Study). Inflammation (measured with CRP) was assessed repeatedly over 6 years (i.e. Year 2, 4, 6, & 8). Brain MRIs were obtained at years 10-11 with DTI; regions of interest included late-myelinating areas vulnerable to aging, including frontal-parietal [superior longitudinal fasciculus (SLF)-dorsal] and temporal (SLF-temporal; uncinate) white matter tracts. Mean CRP values significantly declined (t=-5.54, p<.0001) over 8 years, and subject-specific slopes (BLUPs) all showed a decline (mean=-.57, SD=.53). More than 50% of study participants were still in the moderate to high cardiovascular risk range based on CRP values at Year 8. After controlling for demographics, vascular risk factors and MRI white matter hyperintensities, larger decreases in CRP values over time were significantly associated with higher fractional anisotropy in the SLF-dorsal [Beta=-0.0052, standard error (SE)=0.003; 95% confidence interval (CI)= -0.0103 to -0.0025, p =.04], SLF-temporal (Beta=-0.0109, SE=0.004; 95%CI=-0.0189 to -0.0029, p =.008), and uncinate (Beta=-0.0067, SE=0.003; 95%CI=-0.0132 to -0.0001, p =.05) fasciculi. Results suggest that in a prospective cohort of older individuals, faster declines in inflammation over time are related to indicators of white matter health, even after accounting for vascular risk factors." @default.
- W2068777742 created "2016-06-24" @default.
- W2068777742 creator A5007432044 @default.
- W2068777742 creator A5015228664 @default.
- W2068777742 creator A5017749001 @default.
- W2068777742 creator A5018722034 @default.
- W2068777742 creator A5022120351 @default.
- W2068777742 creator A5038974466 @default.
- W2068777742 creator A5062324929 @default.
- W2068777742 creator A5067387552 @default.
- W2068777742 creator A5078009095 @default.
- W2068777742 creator A5081107493 @default.
- W2068777742 creator A5087201620 @default.
- W2068777742 date "2014-07-01" @default.
- W2068777742 modified "2023-09-23" @default.
- W2068777742 title "P3-190: DECLINES IN INFLAMMATION PREDICT GREATER WHITE MATTER INTEGRITY IN OLDER ADULTS" @default.
- W2068777742 doi "https://doi.org/10.1016/j.jalz.2014.05.1280" @default.
- W2068777742 hasPublicationYear "2014" @default.
- W2068777742 type Work @default.
- W2068777742 sameAs 2068777742 @default.
- W2068777742 citedByCount "0" @default.
- W2068777742 crossrefType "journal-article" @default.
- W2068777742 hasAuthorship W2068777742A5007432044 @default.
- W2068777742 hasAuthorship W2068777742A5015228664 @default.
- W2068777742 hasAuthorship W2068777742A5017749001 @default.
- W2068777742 hasAuthorship W2068777742A5018722034 @default.
- W2068777742 hasAuthorship W2068777742A5022120351 @default.
- W2068777742 hasAuthorship W2068777742A5038974466 @default.
- W2068777742 hasAuthorship W2068777742A5062324929 @default.
- W2068777742 hasAuthorship W2068777742A5067387552 @default.
- W2068777742 hasAuthorship W2068777742A5078009095 @default.
- W2068777742 hasAuthorship W2068777742A5081107493 @default.
- W2068777742 hasAuthorship W2068777742A5087201620 @default.
- W2068777742 hasBestOaLocation W20687777421 @default.
- W2068777742 hasConcept C126322002 @default.
- W2068777742 hasConcept C126838900 @default.
- W2068777742 hasConcept C143409427 @default.
- W2068777742 hasConcept C146638467 @default.
- W2068777742 hasConcept C164705383 @default.
- W2068777742 hasConcept C188816634 @default.
- W2068777742 hasConcept C2776914184 @default.
- W2068777742 hasConcept C2781192897 @default.
- W2068777742 hasConcept C44249647 @default.
- W2068777742 hasConcept C71924100 @default.
- W2068777742 hasConcept C72563966 @default.
- W2068777742 hasConcept C89916169 @default.
- W2068777742 hasConceptScore W2068777742C126322002 @default.
- W2068777742 hasConceptScore W2068777742C126838900 @default.
- W2068777742 hasConceptScore W2068777742C143409427 @default.
- W2068777742 hasConceptScore W2068777742C146638467 @default.
- W2068777742 hasConceptScore W2068777742C164705383 @default.
- W2068777742 hasConceptScore W2068777742C188816634 @default.
- W2068777742 hasConceptScore W2068777742C2776914184 @default.
- W2068777742 hasConceptScore W2068777742C2781192897 @default.
- W2068777742 hasConceptScore W2068777742C44249647 @default.
- W2068777742 hasConceptScore W2068777742C71924100 @default.
- W2068777742 hasConceptScore W2068777742C72563966 @default.
- W2068777742 hasConceptScore W2068777742C89916169 @default.
- W2068777742 hasIssue "4S_Part_19" @default.
- W2068777742 hasLocation W20687777421 @default.
- W2068777742 hasOpenAccess W2068777742 @default.
- W2068777742 hasPrimaryLocation W20687777421 @default.
- W2068777742 hasRelatedWork W2039717395 @default.
- W2068777742 hasRelatedWork W2082252904 @default.
- W2068777742 hasRelatedWork W2343606810 @default.
- W2068777742 hasRelatedWork W2392570167 @default.
- W2068777742 hasRelatedWork W2887545892 @default.
- W2068777742 hasRelatedWork W2913949717 @default.
- W2068777742 hasRelatedWork W2999113798 @default.
- W2068777742 hasRelatedWork W4242126726 @default.
- W2068777742 hasRelatedWork W4281754482 @default.
- W2068777742 hasRelatedWork W4323543371 @default.
- W2068777742 hasVolume "10" @default.
- W2068777742 isParatext "false" @default.
- W2068777742 isRetracted "false" @default.
- W2068777742 magId "2068777742" @default.
- W2068777742 workType "article" @default.