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- W2068781659 abstract "The migration of oligodendrocyte progenitor cells (OPCs) to the white matter is an indispensable requirement for an intact brain function. The mechanism of cell migration in general is not yet completely understood. Nevertheless, evidence is accumulating that besides the coordinated rearrangement of the cytoskeleton, a finetuned interplay of ion and water fluxes across the cell membrane is essential for cell migration. One part of a general hypothesis is that a local volume increase towards the direction of movement triggers a mechano-activated calcium influx that regulates various procedures at the rear end of a migrating cell. Here, we investigated cell volume changes of migrating OPCs using scanning ion conductance microscopy. We found that during accelerated migration OPCs undergo an increase in the frontal cell body volume. These findings are supplemented with time lapse calcium imaging data that hint an increase in calcium content the frontal part of the cell soma." @default.
- W2068781659 created "2016-06-24" @default.
- W2068781659 creator A5006613979 @default.
- W2068781659 creator A5021076423 @default.
- W2068781659 creator A5033626190 @default.
- W2068781659 creator A5052729954 @default.
- W2068781659 date "2013-05-09" @default.
- W2068781659 modified "2023-09-25" @default.
- W2068781659 title "Migrating Oligodendrocyte Progenitor Cells Swell Prior to Soma Dislocation" @default.
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- W2068781659 doi "https://doi.org/10.1038/srep01806" @default.
- W2068781659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3648797" @default.
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- W2068781659 hasPublicationYear "2013" @default.
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