FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068786072> ?p ?o ?g. }

• W2068786072 endingPage "372" @default.
• W2068786072 startingPage "365" @default.
• W2068786072 abstract "To examine the role of protein kinase C as a chronic regulator of proximal tubule Na/H antiporter activity, the effect of phorbol 12-myristate 13-acetate (PMA) on the Na/H antiporter was studied in cultured proximal tubule cells. Short-term activation of protein kinase C by 5 min exposure to PMA caused an acute increase in Na/H antiporter activity that was not prevented by cycloheximide or actinomycin D and did not persist 24 h later. Long-term activation of protein kinase C by 2 h exposure to PMA caused a dose-dependent increase in Na/H antiporter activity 24 h later. This latter effect was due to protein kinase C activation in that it was inhibited by sphingosine and was not seen with 4 alpha-PMA, an inactive analogue. The chronic effect of PMA was inhibited by 10 nM actinomycin D or 7 microM cycloheximide. Proximal tubule cells exposed to PMA for 2 h demonstrated a two- to threefold increase in Na/H antiporter mRNA (mRNANa/H) abundance 4 h later. In conclusion, short-term activation of protein kinase C leads to a transient increase in Na/H antiporter activity that is independent of transcription and translation, whereas long-term activation of protein kinase C causes a persistent increase in antiporter activity that is dependent on transcription and translation and is associated with increased mRNANa/H abundance. This latter effect may mediate increased Na/H antiporter activity in a number of chronic conditions." @default.
• W2068786072 created "2016-06-24" @default.
• W2068786072 creator A5023488815 @default.
• W2068786072 creator A5033861833 @default.
• W2068786072 creator A5035732349 @default.
• W2068786072 creator A5082066515 @default.
• W2068786072 date "1992-02-01" @default.
• W2068786072 modified "2023-10-09" @default.
• W2068786072 title "Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells." @default.
• W2068786072 cites W1485079524 @default.
• W2068786072 cites W1492524414 @default.
• W2068786072 cites W1497518126 @default.
• W2068786072 cites W1501290049 @default.
• W2068786072 cites W1555606052 @default.
• W2068786072 cites W1595294831 @default.
• W2068786072 cites W1785287191 @default.
• W2068786072 cites W1967989557 @default.
• W2068786072 cites W1972511948 @default.
• W2068786072 cites W1982332387 @default.
• W2068786072 cites W1988354883 @default.
• W2068786072 cites W1989873313 @default.
• W2068786072 cites W1995216460 @default.
• W2068786072 cites W1999488417 @default.
• W2068786072 cites W2025100148 @default.
• W2068786072 cites W2029252387 @default.
• W2068786072 cites W2033990219 @default.
• W2068786072 cites W2037725098 @default.
• W2068786072 cites W2040636772 @default.
• W2068786072 cites W2047005351 @default.
• W2068786072 cites W2050431245 @default.
• W2068786072 cites W2052977964 @default.
• W2068786072 cites W2056692449 @default.
• W2068786072 cites W2057595921 @default.
• W2068786072 cites W2067388503 @default.
• W2068786072 cites W2072954278 @default.
• W2068786072 cites W2075504174 @default.
• W2068786072 cites W2077311163 @default.
• W2068786072 cites W2080480553 @default.
• W2068786072 cites W2083869788 @default.
• W2068786072 cites W2091319839 @default.
• W2068786072 cites W2092236370 @default.
• W2068786072 cites W2116938316 @default.
• W2068786072 cites W2122668255 @default.
• W2068786072 cites W2123715163 @default.
• W2068786072 cites W2137035221 @default.
• W2068786072 cites W2143006710 @default.
• W2068786072 cites W2157757041 @default.
• W2068786072 cites W2265051756 @default.
• W2068786072 cites W2290636374 @default.
• W2068786072 cites W2398046464 @default.
• W2068786072 cites W2414958282 @default.
• W2068786072 cites W2429587076 @default.
• W2068786072 cites W2438233272 @default.
• W2068786072 cites W2460519045 @default.
• W2068786072 cites W312324579 @default.
• W2068786072 cites W4238605098 @default.
• W2068786072 doi "https://doi.org/10.1172/jci115594" @default.
• W2068786072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/442861" @default.
• W2068786072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1310692" @default.
• W2068786072 hasPublicationYear "1992" @default.
• W2068786072 type Work @default.
• W2068786072 sameAs 2068786072 @default.
• W2068786072 citedByCount "48" @default.
• W2068786072 crossrefType "journal-article" @default.
• W2068786072 hasAuthorship W2068786072A5023488815 @default.
• W2068786072 hasAuthorship W2068786072A5033861833 @default.
• W2068786072 hasAuthorship W2068786072A5035732349 @default.
• W2068786072 hasAuthorship W2068786072A5082066515 @default.
• W2068786072 hasBestOaLocation W20687860721 @default.
• W2068786072 hasConcept C114574056 @default.
• W2068786072 hasConcept C153911025 @default.
• W2068786072 hasConcept C178790620 @default.
• W2068786072 hasConcept C184235292 @default.
• W2068786072 hasConcept C185592680 @default.
• W2068786072 hasConcept C195794163 @default.
• W2068786072 hasConcept C2778128677 @default.
• W2068786072 hasConcept C2780043322 @default.
• W2068786072 hasConcept C3675279 @default.
• W2068786072 hasConcept C41625074 @default.
• W2068786072 hasConcept C537181965 @default.
• W2068786072 hasConcept C55493867 @default.
• W2068786072 hasConcept C57181701 @default.
• W2068786072 hasConcept C86803240 @default.
• W2068786072 hasConcept C97029542 @default.
• W2068786072 hasConceptScore W2068786072C114574056 @default.
• W2068786072 hasConceptScore W2068786072C153911025 @default.
• W2068786072 hasConceptScore W2068786072C178790620 @default.
• W2068786072 hasConceptScore W2068786072C184235292 @default.
• W2068786072 hasConceptScore W2068786072C185592680 @default.
• W2068786072 hasConceptScore W2068786072C195794163 @default.
• W2068786072 hasConceptScore W2068786072C2778128677 @default.
• W2068786072 hasConceptScore W2068786072C2780043322 @default.
• W2068786072 hasConceptScore W2068786072C3675279 @default.
• W2068786072 hasConceptScore W2068786072C41625074 @default.
• W2068786072 hasConceptScore W2068786072C537181965 @default.
• W2068786072 hasConceptScore W2068786072C55493867 @default.
• W2068786072 hasConceptScore W2068786072C57181701 @default.
• W2068786072 hasConceptScore W2068786072C86803240 @default.

• next