FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068787182> ?p ?o ?g. }

• W2068787182 endingPage "103" @default.
• W2068787182 startingPage "91" @default.
• W2068787182 abstract "1. The cholinesterase inhibitors neostigmine, edrophonium and eserine (7 x 10(-7) M) reduced m.e.p.p. frequency by some 50% at the frog neuromuscular junction. Neostigmine also produced a small reduction in quantal content. 2. Tetraisopropylpyrophosphoramide, with a high specificity for non-specific cholinesterase, has a similar effect on m.e.p.p. frequency but ambenonium, with a high specificity for acetylcholinesterase, was markedly less effective in this respect. 3. Carbachol (10(-5) M) and the muscarinic agonists muscarine and metacholine (7 x 10(-7) M) also reduced the rate of spontaneous release. 4. The action of neostigmine was antagonized by atropine, but not by D-tubocurarine. Muscarine did not have any further effect when m.e.p.p. frequency was reduced with neostigmine. 5. Experiments with reduced extracellular Ca2+ concentration suggest that the cholinergic agents reduce Ca2+ permeability directly at the presynaptic terminals and that they do not act via a change in PNa or PK. It is suggested that the consequent reduction in Ca2+ entry causes a fall in both evoked release and in intracellular Ca2+ concentration, thereby reducing m.e.p.p. frequency. 6. It is concluded that non-specific cholinesterases present on the presynaptic terminals can act as inhibitory muscarinic cholinergic receptors. This form of presynaptic inhibition at the amphibian neuromuscular junction contrasts with that described in the mammalian preparation in which the sites are blocked by D-tubocurarine and are excitatory." @default.
• W2068787182 created "2016-06-24" @default.
• W2068787182 creator A5056572899 @default.
• W2068787182 creator A5077123406 @default.
• W2068787182 date "1979-09-01" @default.
• W2068787182 modified "2023-10-18" @default.
• W2068787182 title "Inhibitory effects of cholinergic agents on the release of transmitter at the frog neuromuscular junction." @default.
• W2068787182 cites W1934179322 @default.
• W2068787182 cites W1945612959 @default.
• W2068787182 cites W1955148788 @default.
• W2068787182 cites W1964800013 @default.
• W2068787182 cites W1969958674 @default.
• W2068787182 cites W1972369330 @default.
• W2068787182 cites W1976017255 @default.
• W2068787182 cites W1979273499 @default.
• W2068787182 cites W1980736469 @default.
• W2068787182 cites W2015718465 @default.
• W2068787182 cites W2036707922 @default.
• W2068787182 cites W2042163759 @default.
• W2068787182 cites W2044210562 @default.
• W2068787182 cites W2044661786 @default.
• W2068787182 cites W2066199544 @default.
• W2068787182 cites W2078342149 @default.
• W2068787182 cites W2090611979 @default.
• W2068787182 cites W2091644278 @default.
• W2068787182 cites W2110841584 @default.
• W2068787182 cites W2122512080 @default.
• W2068787182 cites W2143452465 @default.
• W2068787182 cites W2144785507 @default.
• W2068787182 cites W2165273154 @default.
• W2068787182 cites W2229292388 @default.
• W2068787182 cites W2254661709 @default.
• W2068787182 doi "https://doi.org/10.1113/jphysiol.1979.sp012917" @default.
• W2068787182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1280544" @default.
• W2068787182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/229216" @default.
• W2068787182 hasPublicationYear "1979" @default.
• W2068787182 type Work @default.
• W2068787182 sameAs 2068787182 @default.
• W2068787182 citedByCount "56" @default.
• W2068787182 countsByYear W20687871822014 @default.
• W2068787182 countsByYear W20687871822018 @default.
• W2068787182 crossrefType "journal-article" @default.
• W2068787182 hasAuthorship W2068787182A5056572899 @default.
• W2068787182 hasAuthorship W2068787182A5077123406 @default.
• W2068787182 hasBestOaLocation W20687871822 @default.
• W2068787182 hasConcept C112592302 @default.
• W2068787182 hasConcept C12554922 @default.
• W2068787182 hasConcept C126322002 @default.
• W2068787182 hasConcept C134018914 @default.
• W2068787182 hasConcept C169760540 @default.
• W2068787182 hasConcept C170493617 @default.
• W2068787182 hasConcept C17077164 @default.
• W2068787182 hasConcept C181199279 @default.
• W2068787182 hasConcept C185592680 @default.
• W2068787182 hasConcept C22885893 @default.
• W2068787182 hasConcept C2775859210 @default.
• W2068787182 hasConcept C2775910092 @default.
• W2068787182 hasConcept C2777240379 @default.
• W2068787182 hasConcept C2777411258 @default.
• W2068787182 hasConcept C2778105408 @default.
• W2068787182 hasConcept C2778816929 @default.
• W2068787182 hasConcept C2778988552 @default.
• W2068787182 hasConcept C2779901103 @default.
• W2068787182 hasConcept C2780841807 @default.
• W2068787182 hasConcept C2910532367 @default.
• W2068787182 hasConcept C31896038 @default.
• W2068787182 hasConcept C33789571 @default.
• W2068787182 hasConcept C55493867 @default.
• W2068787182 hasConcept C71924100 @default.
• W2068787182 hasConcept C86803240 @default.
• W2068787182 hasConcept C98274493 @default.
• W2068787182 hasConceptScore W2068787182C112592302 @default.
• W2068787182 hasConceptScore W2068787182C12554922 @default.
• W2068787182 hasConceptScore W2068787182C126322002 @default.
• W2068787182 hasConceptScore W2068787182C134018914 @default.
• W2068787182 hasConceptScore W2068787182C169760540 @default.
• W2068787182 hasConceptScore W2068787182C170493617 @default.
• W2068787182 hasConceptScore W2068787182C17077164 @default.
• W2068787182 hasConceptScore W2068787182C181199279 @default.
• W2068787182 hasConceptScore W2068787182C185592680 @default.
• W2068787182 hasConceptScore W2068787182C22885893 @default.
• W2068787182 hasConceptScore W2068787182C2775859210 @default.
• W2068787182 hasConceptScore W2068787182C2775910092 @default.
• W2068787182 hasConceptScore W2068787182C2777240379 @default.
• W2068787182 hasConceptScore W2068787182C2777411258 @default.
• W2068787182 hasConceptScore W2068787182C2778105408 @default.
• W2068787182 hasConceptScore W2068787182C2778816929 @default.
• W2068787182 hasConceptScore W2068787182C2778988552 @default.
• W2068787182 hasConceptScore W2068787182C2779901103 @default.
• W2068787182 hasConceptScore W2068787182C2780841807 @default.
• W2068787182 hasConceptScore W2068787182C2910532367 @default.
• W2068787182 hasConceptScore W2068787182C31896038 @default.
• W2068787182 hasConceptScore W2068787182C33789571 @default.
• W2068787182 hasConceptScore W2068787182C55493867 @default.
• W2068787182 hasConceptScore W2068787182C71924100 @default.
• W2068787182 hasConceptScore W2068787182C86803240 @default.
• W2068787182 hasConceptScore W2068787182C98274493 @default.
• W2068787182 hasIssue "1" @default.

• next