FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068797349> ?p ?o ?g. }

• W2068797349 endingPage "F576" @default.
• W2068797349 startingPage "F571" @default.
• W2068797349 abstract "Endotoxin-related acute kidney injury has been shown to profoundly induce nitric oxide (NO), which activates sympathetic and renin-angiotensin system, resulting in renal vasoconstriction. While vascular muscle cells are known to upregulate inducible NO synthase (iNOS), less is known about the endothelium as a source of NO during endotoxemia. Studies were, therefore, undertaken both in vitro in mouse microvascular endothelial cells and in vivo in transgenic mice with overexpression of endothelial GTP cyclohydrolase, the rate-limiting enzyme for tetrahydrobiopterin, a cofactor for NO synthase. LPS significantly induced endothelial cell iNOS expression and NO concentration in the culture media, with no change in endothelial NO synthase expression. GTP cyclohydrolase-1 transgenic (Tg) mice demonstrated a significant increase in baseline urine NO-to-creatinine ratio and a more significant increase in renal iNOS expression and serum NO levels with LPS treatment compared with the wild-type (WT) mice. Glomerular filtration rate and renal blood flow decreased significantly in Tg mice with 1.0 mg/kg LPS, while no changes were observed in WT with the same dose of LPS. Serum IL-6 levels were significantly higher in Tg compared with WT mice during endotoxemia. The antioxidant tempol improved the glomerular filtration rate in the Tg mice. Thus endothelium can be an important source of iNOS and serum NO concentration during endotoxemia, thereby increasing the sensitivity to AKI. Reactive oxygen species appear to be involved in this acute renal injury in Tg mice during endotoxemia." @default.
• W2068797349 created "2016-06-24" @default.
• W2068797349 creator A5000195279 @default.
• W2068797349 creator A5001702929 @default.
• W2068797349 creator A5009700893 @default.
• W2068797349 creator A5010416869 @default.
• W2068797349 creator A5040065258 @default.
• W2068797349 creator A5046597133 @default.
• W2068797349 creator A5057592691 @default.
• W2068797349 creator A5076869715 @default.
• W2068797349 creator A5077097017 @default.
• W2068797349 creator A5086649279 @default.
• W2068797349 date "2008-03-01" @default.
• W2068797349 modified "2023-10-14" @default.
• W2068797349 title "Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1" @default.
• W2068797349 cites W190394174 @default.
• W2068797349 cites W2019117547 @default.
• W2068797349 cites W2044263892 @default.
• W2068797349 cites W2049927822 @default.
• W2068797349 cites W2052391094 @default.
• W2068797349 cites W2065578442 @default.
• W2068797349 cites W2104010066 @default.
• W2068797349 cites W2104326163 @default.
• W2068797349 cites W2120268554 @default.
• W2068797349 cites W2121154174 @default.
• W2068797349 cites W2126624094 @default.
• W2068797349 cites W2132590612 @default.
• W2068797349 cites W2136270624 @default.
• W2068797349 cites W2137982463 @default.
• W2068797349 cites W2151517451 @default.
• W2068797349 cites W2154986839 @default.
• W2068797349 cites W2169782569 @default.
• W2068797349 cites W2170568009 @default.
• W2068797349 cites W4238559979 @default.
• W2068797349 doi "https://doi.org/10.1152/ajprenal.00538.2007" @default.
• W2068797349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18171994" @default.
• W2068797349 hasPublicationYear "2008" @default.
• W2068797349 type Work @default.
• W2068797349 sameAs 2068797349 @default.
• W2068797349 citedByCount "18" @default.
• W2068797349 countsByYear W20687973492012 @default.
• W2068797349 countsByYear W20687973492013 @default.
• W2068797349 countsByYear W20687973492015 @default.
• W2068797349 countsByYear W20687973492017 @default.
• W2068797349 countsByYear W20687973492019 @default.
• W2068797349 countsByYear W20687973492020 @default.
• W2068797349 countsByYear W20687973492021 @default.
• W2068797349 countsByYear W20687973492022 @default.
• W2068797349 crossrefType "journal-article" @default.
• W2068797349 hasAuthorship W2068797349A5000195279 @default.
• W2068797349 hasAuthorship W2068797349A5001702929 @default.
• W2068797349 hasAuthorship W2068797349A5009700893 @default.
• W2068797349 hasAuthorship W2068797349A5010416869 @default.
• W2068797349 hasAuthorship W2068797349A5040065258 @default.
• W2068797349 hasAuthorship W2068797349A5046597133 @default.
• W2068797349 hasAuthorship W2068797349A5057592691 @default.
• W2068797349 hasAuthorship W2068797349A5076869715 @default.
• W2068797349 hasAuthorship W2068797349A5077097017 @default.
• W2068797349 hasAuthorship W2068797349A5086649279 @default.
• W2068797349 hasBestOaLocation W20687973492 @default.
• W2068797349 hasConcept C126322002 @default.
• W2068797349 hasConcept C134018914 @default.
• W2068797349 hasConcept C142225936 @default.
• W2068797349 hasConcept C185592680 @default.
• W2068797349 hasConcept C2775956414 @default.
• W2068797349 hasConcept C2776145790 @default.
• W2068797349 hasConcept C2776992346 @default.
• W2068797349 hasConcept C2777622882 @default.
• W2068797349 hasConcept C2780091579 @default.
• W2068797349 hasConcept C2780472472 @default.
• W2068797349 hasConcept C519581460 @default.
• W2068797349 hasConcept C71924100 @default.
• W2068797349 hasConcept C86803240 @default.
• W2068797349 hasConceptScore W2068797349C126322002 @default.
• W2068797349 hasConceptScore W2068797349C134018914 @default.
• W2068797349 hasConceptScore W2068797349C142225936 @default.
• W2068797349 hasConceptScore W2068797349C185592680 @default.
• W2068797349 hasConceptScore W2068797349C2775956414 @default.
• W2068797349 hasConceptScore W2068797349C2776145790 @default.
• W2068797349 hasConceptScore W2068797349C2776992346 @default.
• W2068797349 hasConceptScore W2068797349C2777622882 @default.
• W2068797349 hasConceptScore W2068797349C2780091579 @default.
• W2068797349 hasConceptScore W2068797349C2780472472 @default.
• W2068797349 hasConceptScore W2068797349C519581460 @default.
• W2068797349 hasConceptScore W2068797349C71924100 @default.
• W2068797349 hasConceptScore W2068797349C86803240 @default.
• W2068797349 hasIssue "3" @default.
• W2068797349 hasLocation W20687973491 @default.
• W2068797349 hasLocation W20687973492 @default.
• W2068797349 hasLocation W20687973493 @default.
• W2068797349 hasOpenAccess W2068797349 @default.
• W2068797349 hasPrimaryLocation W20687973491 @default.
• W2068797349 hasRelatedWork W1996173977 @default.
• W2068797349 hasRelatedWork W2035049009 @default.
• W2068797349 hasRelatedWork W2037000455 @default.
• W2068797349 hasRelatedWork W2072306117 @default.
• W2068797349 hasRelatedWork W2077855449 @default.
• W2068797349 hasRelatedWork W2092857037 @default.

• next