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- W2068800704 abstract "The effect of bradykinin (BK) on proteinase activity, prostaglandin synthesis, and the production of interleukin-6 (IL-6) was investigated in cultures of human osteoblast-like cells. Bradykinin had no effect on stromelysin activity and plasminogen activator activity produced by human osteoblast-like cells. However, BK stimulated the production of prostaglandin E2, an effect that was markedly enhanced by pre-incubation with recombinant interleukin-1 alpha (rhIL-1α), but was apparently unaffected by BK receptor antagonists types 1 and 2. Bradykinin stimulated the intracellular accumulation of total inositol phosphates suggesting that its effects were mediated by stimulation of phosphoinositide metabolism. Bradykinin within the dose range of 1011−105 M also significantly stimulated the production of IL-6. Bradykinin may, therefore, mediate a variety of responses in bone under both physiological and pathological conditions." @default.
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- W2068800704 date "1992-04-01" @default.
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- W2068800704 title "Bradykinin stimulates the production of prostaglandin E2 and interleukin-6 in human osteoblast-like cells" @default.
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- W2068800704 doi "https://doi.org/10.1016/0167-4889(92)90172-8" @default.
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