Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068807020> ?p ?o ?g. }
- W2068807020 endingPage "394" @default.
- W2068807020 startingPage "390" @default.
- W2068807020 abstract "This study presents our findings on the extent of neuronal damage in the hippocampal CA1–4 subfields following global (forebrain) cerebral ischemia in rats when using different blood pressure levels (37 vs 45 mmHg) and bilateral carotid occlusion durations (8 vs 10 min) under isoflurane anesthesia. We observed that global ischemia induced at a blood pressure of 37 mmHg resulted in high-grade CA1 neuron injury (>90%) at either duration of carotid occlusion. In contrast, global ischemia induced at a blood pressure of 45 mmHg resulted in either high-grade CA1 neuronal loss or a neuronal loss of ≈50% or less. We also noted that a post-reperfusion EEG recovery time (return of burst suppression spikes) of >12 min was associated with an 85% rate of high-grade CA1 neuronal injury. Neuronal loss in the other hippocampal subfields did not differ significantly between any of the 4 different model parameters tested. In these subfields ≈55% neuronal loss occurred in the CA2 subfield, and ≈30% in the CA3 and CA4 subfields. These findings highlight the need to assess different model parameters in order to achieve consistent high-grade CA1 neuronal damage, which, among other experimental outcomes, will improve the ability to uncover therapeutic effects using the least possible animals when assessing a neuroprotective treatment." @default.
- W2068807020 created "2016-06-24" @default.
- W2068807020 creator A5028165423 @default.
- W2068807020 creator A5048244553 @default.
- W2068807020 creator A5049716242 @default.
- W2068807020 creator A5067382672 @default.
- W2068807020 creator A5084014102 @default.
- W2068807020 date "2011-11-01" @default.
- W2068807020 modified "2023-09-29" @default.
- W2068807020 title "The effect of blood pressure (37 vs 45mmHg) and carotid occlusion duration (8 vs 10min) on CA1–4 neuronal damage when using isoflurane in a global cerebral ischemia rat model" @default.
- W2068807020 cites W1913635668 @default.
- W2068807020 cites W1964928037 @default.
- W2068807020 cites W1972764493 @default.
- W2068807020 cites W1977383813 @default.
- W2068807020 cites W1993769799 @default.
- W2068807020 cites W2002924541 @default.
- W2068807020 cites W2008283809 @default.
- W2068807020 cites W2016703443 @default.
- W2068807020 cites W2022357814 @default.
- W2068807020 cites W2026989777 @default.
- W2068807020 cites W2040135230 @default.
- W2068807020 cites W2044950786 @default.
- W2068807020 cites W2055381678 @default.
- W2068807020 cites W2073505222 @default.
- W2068807020 cites W2133665180 @default.
- W2068807020 cites W4248683703 @default.
- W2068807020 doi "https://doi.org/10.1016/j.brainresbull.2011.09.005" @default.
- W2068807020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21945086" @default.
- W2068807020 hasPublicationYear "2011" @default.
- W2068807020 type Work @default.
- W2068807020 sameAs 2068807020 @default.
- W2068807020 citedByCount "10" @default.
- W2068807020 countsByYear W20688070202012 @default.
- W2068807020 countsByYear W20688070202013 @default.
- W2068807020 countsByYear W20688070202014 @default.
- W2068807020 countsByYear W20688070202015 @default.
- W2068807020 countsByYear W20688070202016 @default.
- W2068807020 countsByYear W20688070202017 @default.
- W2068807020 countsByYear W20688070202018 @default.
- W2068807020 crossrefType "journal-article" @default.
- W2068807020 hasAuthorship W2068807020A5028165423 @default.
- W2068807020 hasAuthorship W2068807020A5048244553 @default.
- W2068807020 hasAuthorship W2068807020A5049716242 @default.
- W2068807020 hasAuthorship W2068807020A5067382672 @default.
- W2068807020 hasAuthorship W2068807020A5084014102 @default.
- W2068807020 hasConcept C118552586 @default.
- W2068807020 hasConcept C126322002 @default.
- W2068807020 hasConcept C148762608 @default.
- W2068807020 hasConcept C15744967 @default.
- W2068807020 hasConcept C157767197 @default.
- W2068807020 hasConcept C164705383 @default.
- W2068807020 hasConcept C169760540 @default.
- W2068807020 hasConcept C25498285 @default.
- W2068807020 hasConcept C2776268601 @default.
- W2068807020 hasConcept C2776359302 @default.
- W2068807020 hasConcept C2778794669 @default.
- W2068807020 hasConcept C2993744773 @default.
- W2068807020 hasConcept C42219234 @default.
- W2068807020 hasConcept C541997718 @default.
- W2068807020 hasConcept C71924100 @default.
- W2068807020 hasConcept C74254510 @default.
- W2068807020 hasConcept C84393581 @default.
- W2068807020 hasConceptScore W2068807020C118552586 @default.
- W2068807020 hasConceptScore W2068807020C126322002 @default.
- W2068807020 hasConceptScore W2068807020C148762608 @default.
- W2068807020 hasConceptScore W2068807020C15744967 @default.
- W2068807020 hasConceptScore W2068807020C157767197 @default.
- W2068807020 hasConceptScore W2068807020C164705383 @default.
- W2068807020 hasConceptScore W2068807020C169760540 @default.
- W2068807020 hasConceptScore W2068807020C25498285 @default.
- W2068807020 hasConceptScore W2068807020C2776268601 @default.
- W2068807020 hasConceptScore W2068807020C2776359302 @default.
- W2068807020 hasConceptScore W2068807020C2778794669 @default.
- W2068807020 hasConceptScore W2068807020C2993744773 @default.
- W2068807020 hasConceptScore W2068807020C42219234 @default.
- W2068807020 hasConceptScore W2068807020C541997718 @default.
- W2068807020 hasConceptScore W2068807020C71924100 @default.
- W2068807020 hasConceptScore W2068807020C74254510 @default.
- W2068807020 hasConceptScore W2068807020C84393581 @default.
- W2068807020 hasIssue "5-6" @default.
- W2068807020 hasLocation W20688070201 @default.
- W2068807020 hasLocation W20688070202 @default.
- W2068807020 hasOpenAccess W2068807020 @default.
- W2068807020 hasPrimaryLocation W20688070201 @default.
- W2068807020 hasRelatedWork W1540517858 @default.
- W2068807020 hasRelatedWork W1983317203 @default.
- W2068807020 hasRelatedWork W1997267385 @default.
- W2068807020 hasRelatedWork W2089822614 @default.
- W2068807020 hasRelatedWork W2094459837 @default.
- W2068807020 hasRelatedWork W2124734881 @default.
- W2068807020 hasRelatedWork W2371205234 @default.
- W2068807020 hasRelatedWork W2728509079 @default.
- W2068807020 hasRelatedWork W3139770 @default.
- W2068807020 hasRelatedWork W4240885417 @default.
- W2068807020 hasVolume "86" @default.
- W2068807020 isParatext "false" @default.
- W2068807020 isRetracted "false" @default.
- W2068807020 magId "2068807020" @default.