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• W2068807813 abstract "Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer&#39;s disease in the Netherlands Bart Hoogveldt1, Benoît Rive2, Johan Severens3, Khaled Maman4, Chantal Guilhaume51Field Product Management, Lundbeck BV, Amsterdam, The Netherlands; 2Global Outcomes Research, Lundbeck SAS, Issy-les-Moulineaux, France; 3Institute of Health Policy and Management, Erasmus University Rotterdam, The Netherlands; 4Creativ Research SAS, Paris, France; 5Global Evidence and Value Development, Sanofi-Aventis, Paris, FranceObjective: The purpose of this study was to estimate the cost-effectiveness of memantine relative to standard care in patients with moderate-to-severe Alzheimer&#39;s disease in the Netherlands.Methods: A country-adapted five-year Markov model simulated disease progression through a series of states, defined by dependency and disease severity. Transition probabilities were derived from trials, with utility and epidemiological data obtained from a longitudinal Dutch cohort. Cost-effectiveness was described in terms of quality-adjusted life years and time spent in a nondependent state or in a moderate severity state.Results: Memantine monotherapy versus standard care led to 0.058 quality-adjusted life years gained (1.207 versus 1.265), longer time in a nondependent state (from 1.602 to 1.751 years) and in a moderate state (from 2.051 to 2.141 years), and no additional costs (€113,927 versus €110,097). Robustness of results was confirmed through sensitivity analyses.Conclusion: Memantine is dominant compared with standard care in the Netherlands. Results are consistent with similar economic evaluations in other countries.Keywords: memantine, Alzheimer&#39;s disease, cost-effectiveness analysis, Netherlands, cholinesterase inhibitors" @default.
• W2068807813 created "2016-06-24" @default.
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• W2068807813 date "2011-06-01" @default.
• W2068807813 modified "2023-10-18" @default.
• W2068807813 title "Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands" @default.
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• W2068807813 doi "https://doi.org/10.2147/ndt.s19239" @default.
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