Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068807924> ?p ?o ?g. }
- W2068807924 endingPage "e51423" @default.
- W2068807924 startingPage "e51423" @default.
- W2068807924 abstract "It is well known that B-1 B cells are the main cell type that is responsible for the production of natural immunoglobulin M (IgM) and can respond to infection by increasing IgM secretion. However, we unexpectedly found that some epithelial cells also can express rearranged IgM transcript that has natural IgM characteristics, such as germline-encoded and restricted rearrangement patterns. Here we studied IgM expression in human non-B cells and found that IgM was frequently expressed by many human epithelial cancer cells as well as non-cancer epithelial cells. Moreover, CD79A and CD79B, two molecules that are physically linked to membranous IgM on the surface of B cells to form the B cell antigen receptor complex, were also expressed on the cell surface of epithelial cancer cells and co-located with IgM. Like the natural IgM, the epithelial cancer cell-derived IgM recognized a series of microbial antigens, such as single-stranded DNA, double-stranded DNA, lipopolysaccharide, and the HEp-2 cell antigen. More important, stimulation of the toll-like receptor 9 (TLR9), which mimics bacterial infection, substantially increased the secretion of IgM in human epithelial cancer cells. These findings indicate that human epithelial cancer cells as well as non-cancer epithelial cells can spontaneously produce IgM with natural antibody activity." @default.
- W2068807924 created "2016-06-24" @default.
- W2068807924 creator A5002631293 @default.
- W2068807924 creator A5004903867 @default.
- W2068807924 creator A5006583715 @default.
- W2068807924 creator A5027114169 @default.
- W2068807924 creator A5039401370 @default.
- W2068807924 creator A5042576995 @default.
- W2068807924 creator A5043300709 @default.
- W2068807924 creator A5063261966 @default.
- W2068807924 creator A5066716873 @default.
- W2068807924 creator A5081148554 @default.
- W2068807924 creator A5081946864 @default.
- W2068807924 date "2012-12-12" @default.
- W2068807924 modified "2023-10-11" @default.
- W2068807924 title "Spontaneous Production of Immunoglobulin M in Human Epithelial Cancer Cells" @default.
- W2068807924 cites W1514540900 @default.
- W2068807924 cites W1699125867 @default.
- W2068807924 cites W1836679973 @default.
- W2068807924 cites W1956007715 @default.
- W2068807924 cites W1965037168 @default.
- W2068807924 cites W1969617808 @default.
- W2068807924 cites W1973965841 @default.
- W2068807924 cites W1974934197 @default.
- W2068807924 cites W1975637521 @default.
- W2068807924 cites W1979667832 @default.
- W2068807924 cites W1999753166 @default.
- W2068807924 cites W2019382232 @default.
- W2068807924 cites W2020153915 @default.
- W2068807924 cites W2020179925 @default.
- W2068807924 cites W2023309048 @default.
- W2068807924 cites W2024419051 @default.
- W2068807924 cites W2025547510 @default.
- W2068807924 cites W2031823238 @default.
- W2068807924 cites W2033415145 @default.
- W2068807924 cites W2033910859 @default.
- W2068807924 cites W2036364776 @default.
- W2068807924 cites W2037879764 @default.
- W2068807924 cites W2042437855 @default.
- W2068807924 cites W2045384882 @default.
- W2068807924 cites W2053877829 @default.
- W2068807924 cites W2054801930 @default.
- W2068807924 cites W2062671046 @default.
- W2068807924 cites W2065558544 @default.
- W2068807924 cites W2073102372 @default.
- W2068807924 cites W2073664216 @default.
- W2068807924 cites W2076791132 @default.
- W2068807924 cites W2082143240 @default.
- W2068807924 cites W2082624239 @default.
- W2068807924 cites W2083036309 @default.
- W2068807924 cites W2090940318 @default.
- W2068807924 cites W2095345037 @default.
- W2068807924 cites W2101773396 @default.
- W2068807924 cites W2109405330 @default.
- W2068807924 cites W2116933950 @default.
- W2068807924 cites W2120896592 @default.
- W2068807924 cites W2132078058 @default.
- W2068807924 cites W2145134132 @default.
- W2068807924 cites W2151393500 @default.
- W2068807924 cites W2154143786 @default.
- W2068807924 cites W2159021562 @default.
- W2068807924 cites W2168522148 @default.
- W2068807924 cites W2168738211 @default.
- W2068807924 cites W2172078968 @default.
- W2068807924 cites W2172246726 @default.
- W2068807924 cites W262665101 @default.
- W2068807924 cites W4236840182 @default.
- W2068807924 doi "https://doi.org/10.1371/journal.pone.0051423" @default.
- W2068807924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3520907" @default.
- W2068807924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23251529" @default.
- W2068807924 hasPublicationYear "2012" @default.
- W2068807924 type Work @default.
- W2068807924 sameAs 2068807924 @default.
- W2068807924 citedByCount "37" @default.
- W2068807924 countsByYear W20688079242013 @default.
- W2068807924 countsByYear W20688079242014 @default.
- W2068807924 countsByYear W20688079242015 @default.
- W2068807924 countsByYear W20688079242016 @default.
- W2068807924 countsByYear W20688079242017 @default.
- W2068807924 countsByYear W20688079242019 @default.
- W2068807924 countsByYear W20688079242020 @default.
- W2068807924 countsByYear W20688079242021 @default.
- W2068807924 countsByYear W20688079242022 @default.
- W2068807924 countsByYear W20688079242023 @default.
- W2068807924 crossrefType "journal-article" @default.
- W2068807924 hasAuthorship W2068807924A5002631293 @default.
- W2068807924 hasAuthorship W2068807924A5004903867 @default.
- W2068807924 hasAuthorship W2068807924A5006583715 @default.
- W2068807924 hasAuthorship W2068807924A5027114169 @default.
- W2068807924 hasAuthorship W2068807924A5039401370 @default.
- W2068807924 hasAuthorship W2068807924A5042576995 @default.
- W2068807924 hasAuthorship W2068807924A5043300709 @default.
- W2068807924 hasAuthorship W2068807924A5063261966 @default.
- W2068807924 hasAuthorship W2068807924A5066716873 @default.
- W2068807924 hasAuthorship W2068807924A5081148554 @default.
- W2068807924 hasAuthorship W2068807924A5081946864 @default.
- W2068807924 hasBestOaLocation W20688079241 @default.
- W2068807924 hasConcept C104317684 @default.