Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068809543> ?p ?o ?g. }
- W2068809543 endingPage "109" @default.
- W2068809543 startingPage "101" @default.
- W2068809543 abstract "To identify oncogene amplification involved in ovarian carcinogenesis, we studied 21 ovarian carcinomas and 5 serous borderline tumors using conventional comparative genomic hybridization (CGH) and CGH to a genomic DNA microarray. Immunohistochemical analysis of the proteins encoded by the genes that were amplified frequently (FGF3/4, FGFR1, CCNE1, PAK1, JUNB, and MDM2) was performed on a tissue microarray comprising 254 cases of ovarian neoplasms. Regarding histologic type, characteristic patterns of copy number changes were revealed. They correlated with histologic tumor type and with intratumoral heterogeneity. Gain of FGF3/4 and CCNE1 was found in all serous carcinomas. Endometrioid carcinomas most frequently showed gain of JUNB (83%), KRAS2 (67%), MYCN (50%), ESR (50%), and CCND2 (50%). Of the serous borderline tumors, 80% harbored amplification of FGFR1 and MDM2 and a 75% gain of PIK3CA. Only CCNE1 immunoreactivity was significantly correlated with CGH results (P < .05) and postoperative survival (P < .05). Microarray-based genomic analysis in combination with immunohistochemical analysis was found to be a powerful technique for identification of clinically relevant gene amplification in human ovarian cancer." @default.
- W2068809543 created "2016-06-24" @default.
- W2068809543 creator A5010411259 @default.
- W2068809543 creator A5020223648 @default.
- W2068809543 creator A5050316905 @default.
- W2068809543 creator A5052884091 @default.
- W2068809543 creator A5063170046 @default.
- W2068809543 creator A5069726714 @default.
- W2068809543 creator A5083705585 @default.
- W2068809543 creator A5086317507 @default.
- W2068809543 date "2006-07-01" @default.
- W2068809543 modified "2023-10-17" @default.
- W2068809543 title "Analysis of Gene Amplification and Prognostic Markers in Ovarian Cancer Using Comparative Genomic Hybridization for Microarrays and Immunohistochemical Analysis for Tissue Microarrays" @default.
- W2068809543 cites W1482714567 @default.
- W2068809543 cites W1491185462 @default.
- W2068809543 cites W1502595730 @default.
- W2068809543 cites W1542117945 @default.
- W2068809543 cites W1544432944 @default.
- W2068809543 cites W1583886175 @default.
- W2068809543 cites W1895365641 @default.
- W2068809543 cites W1965684736 @default.
- W2068809543 cites W1966586745 @default.
- W2068809543 cites W1968046362 @default.
- W2068809543 cites W1974121187 @default.
- W2068809543 cites W1984253811 @default.
- W2068809543 cites W1985906092 @default.
- W2068809543 cites W2004311983 @default.
- W2068809543 cites W2004575269 @default.
- W2068809543 cites W2013216643 @default.
- W2068809543 cites W2019729084 @default.
- W2068809543 cites W2021197128 @default.
- W2068809543 cites W2044510046 @default.
- W2068809543 cites W2069991737 @default.
- W2068809543 cites W2070841378 @default.
- W2068809543 cites W2071110838 @default.
- W2068809543 cites W2081124965 @default.
- W2068809543 cites W2087539081 @default.
- W2068809543 cites W2127301911 @default.
- W2068809543 cites W2152107294 @default.
- W2068809543 cites W2154692501 @default.
- W2068809543 cites W2158728799 @default.
- W2068809543 cites W2163588864 @default.
- W2068809543 cites W2322441397 @default.
- W2068809543 cites W2391575159 @default.
- W2068809543 cites W2628053793 @default.
- W2068809543 doi "https://doi.org/10.1309/n6x5mb24bp42kp20" @default.
- W2068809543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16753589" @default.
- W2068809543 hasPublicationYear "2006" @default.
- W2068809543 type Work @default.
- W2068809543 sameAs 2068809543 @default.
- W2068809543 citedByCount "77" @default.
- W2068809543 countsByYear W20688095432012 @default.
- W2068809543 countsByYear W20688095432013 @default.
- W2068809543 countsByYear W20688095432014 @default.
- W2068809543 countsByYear W20688095432015 @default.
- W2068809543 countsByYear W20688095432016 @default.
- W2068809543 countsByYear W20688095432017 @default.
- W2068809543 countsByYear W20688095432018 @default.
- W2068809543 countsByYear W20688095432019 @default.
- W2068809543 countsByYear W20688095432021 @default.
- W2068809543 countsByYear W20688095432022 @default.
- W2068809543 countsByYear W20688095432023 @default.
- W2068809543 crossrefType "journal-article" @default.
- W2068809543 hasAuthorship W2068809543A5010411259 @default.
- W2068809543 hasAuthorship W2068809543A5020223648 @default.
- W2068809543 hasAuthorship W2068809543A5050316905 @default.
- W2068809543 hasAuthorship W2068809543A5052884091 @default.
- W2068809543 hasAuthorship W2068809543A5063170046 @default.
- W2068809543 hasAuthorship W2068809543A5069726714 @default.
- W2068809543 hasAuthorship W2068809543A5083705585 @default.
- W2068809543 hasAuthorship W2068809543A5086317507 @default.
- W2068809543 hasBestOaLocation W20688095431 @default.
- W2068809543 hasConcept C104317684 @default.
- W2068809543 hasConcept C121608353 @default.
- W2068809543 hasConcept C124942203 @default.
- W2068809543 hasConcept C142724271 @default.
- W2068809543 hasConcept C150173356 @default.
- W2068809543 hasConcept C193270364 @default.
- W2068809543 hasConcept C204232928 @default.
- W2068809543 hasConcept C2780427987 @default.
- W2068809543 hasConcept C30481170 @default.
- W2068809543 hasConcept C502942594 @default.
- W2068809543 hasConcept C54355233 @default.
- W2068809543 hasConcept C555283112 @default.
- W2068809543 hasConcept C71924100 @default.
- W2068809543 hasConcept C7602840 @default.
- W2068809543 hasConcept C86803240 @default.
- W2068809543 hasConceptScore W2068809543C104317684 @default.
- W2068809543 hasConceptScore W2068809543C121608353 @default.
- W2068809543 hasConceptScore W2068809543C124942203 @default.
- W2068809543 hasConceptScore W2068809543C142724271 @default.
- W2068809543 hasConceptScore W2068809543C150173356 @default.
- W2068809543 hasConceptScore W2068809543C193270364 @default.
- W2068809543 hasConceptScore W2068809543C204232928 @default.
- W2068809543 hasConceptScore W2068809543C2780427987 @default.
- W2068809543 hasConceptScore W2068809543C30481170 @default.
- W2068809543 hasConceptScore W2068809543C502942594 @default.
- W2068809543 hasConceptScore W2068809543C54355233 @default.