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- W2068822045 endingPage "54" @default.
- W2068822045 startingPage "45" @default.
- W2068822045 abstract "Pancreatic ductal adenocarcinoma (PDAC) remains one of the poorest prognosis neoplasms. It is typified by high levels of genomic aberrations and copy-number variation, intra-tumoural heterogeneity and resistance to conventional chemotherapy. Improved therapeutic options, ideally targeted against cancer-specific biological mechanisms, are urgently needed. Although induction of DNA damage and/or modulation of DNA damage response pathways are associated with the activity of a number of conventional PDAC chemotherapies, the effectiveness of this approach in the treatment of PDAC has not been comprehensively reviewed. Here, we review chemotherapeutic agents that have shown anti-cancer activity in PDAC and whose mechanisms of action involve modulation of DNA repair pathways. In addition, we highlight novel potential targets within these pathways based on the emerging understanding of PDAC biology and their exploitation as targets in other cancers." @default.
- W2068822045 created "2016-06-24" @default.
- W2068822045 creator A5052773854 @default.
- W2068822045 creator A5062463987 @default.
- W2068822045 creator A5063738443 @default.
- W2068822045 creator A5075772884 @default.
- W2068822045 date "2014-08-01" @default.
- W2068822045 modified "2023-09-24" @default.
- W2068822045 title "Opportunities for translation: Targeting DNA repair pathways in pancreatic cancer" @default.
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