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- W2068831455 abstract "Thirty-four cases of carcinoma of the human large intestine were studied employing a battery of histochemical techniques to identify and characterize mucosubstances, including galactose oxidase-Schiff (GOS) reaction and stain-ings with horseradish peroxidase-labeled lectins. The results disclosed that the goblet cell-type much (GCM) of the left colon differed from that of the right colon in containing 8-O-acetylated N-acetylneuraminic acid (NANA) more abundantly and 8-O-acetylated NANA-(αFuc)-βGal type terminal structures. The right colonic GCM, on the other hand, was shown to contain α Fuc-βGal type predominantly. Surface coat-type mucin (SCM) showed consistent histochemical reactivities regardless of the sites in the large intestine. The transitional mucosa surrounding carcinoma tissues characteristically revealed decreased sulfation and neuraminidase-induced GOS reactivity, suggesting the presence of NANA-β Gal type terminals. The carcinoma tissues resembled the transitional mucosa in showing neuraminidase-induced GOS reactivity, but differed from the latter in possessing intense UEA-I reactivity. The present study indicated that the refined histochemical techniques recently developed were quite useful for understanding the histochemical reactivities correlating with sugar structures. ACTA PATHOL. JPN. 35: 1409–1425, 1985." @default.
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- W2068831455 date "1985-11-01" @default.
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- W2068831455 title "MUCOSUBSTANCE HISTOCHEMISTRY OF THE NORMAL MUCOSA AND CARCINOMA OF THE LARGE INTESTINE: Galactose Oxidase-Schiff Reaction and Lectin Stainings" @default.
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- W2068831455 doi "https://doi.org/10.1111/j.1440-1827.1985.tb01438.x" @default.
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