Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068831743> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2068831743 endingPage "435" @default.
- W2068831743 startingPage "435" @default.
- W2068831743 abstract "Retinoic acid receptor-beta (RAR-beta) is induced by and mediates the growth-inhibitory and apoptotic effects of retinoic acid (RA), suggesting that loss of RAR-beta expression may be one of the critical events involved in the carcinogenesis/ progression of non-small cell lung cancer (NSCLC) and in the responsiveness to retinoid chemotherapy. However, recent contradictory reports that the expression of RAR-beta is associated with poor clinical outcome, and the fact that treatment of serum-deprived type 2 alveolar cells with RA leads to a stimulation of cell proliferation, require the verification of RAR-beta as a biomarker of chemoprevention or prognosis. The expression status of RAR-beta in cancer cells and adjacent normal appearing bronchial epithelium from 39 patients, diagnosed as stage I NSCLC and undergone a curative lung resection, was analyzed in paraffin-embedded tissue sections by IHC staining. The normal appearing bronchial epithelium of 14 out of 33 (42.4%) specimens expressed RAR-beta, whereas 22 out of the 39 (56.4%) stage I NSCLC specimens expressed RAR-beta. RAR-beta was more frequently expressed in the adenocarcinoma (72.7%) than in the squamous cell carcinoma (31.3%) (p=0.026). Neither the expression status in normal appearing adjacent tissue nor that in the tumor tissue had prognostic implications. The higher expression of RAR-beta in cancer tissue, the focal and uneven distribution in normal appearing adjacent bronchial epithelium, and inconsistency with the corresponding tumor tissue, suggest that the expression status of RAR-beta as a biomarker for chemoprevention/early diagnosis or the prognosis of NSCLC requires further consideration." @default.
- W2068831743 created "2016-06-24" @default.
- W2068831743 creator A5011624623 @default.
- W2068831743 creator A5024831387 @default.
- W2068831743 creator A5033640841 @default.
- W2068831743 creator A5040372679 @default.
- W2068831743 creator A5043539481 @default.
- W2068831743 creator A5055306078 @default.
- W2068831743 creator A5075769495 @default.
- W2068831743 creator A5089171427 @default.
- W2068831743 date "2004-01-01" @default.
- W2068831743 modified "2023-10-11" @default.
- W2068831743 title "Retinoic Acid Receptor-β Expression in Stage I Non-Small Cell Lung Cancer and Adjacent Normal Appearing Bronchial Epithelium" @default.
- W2068831743 doi "https://doi.org/10.3349/ymj.2004.45.3.435" @default.
- W2068831743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15227730" @default.
- W2068831743 hasPublicationYear "2004" @default.
- W2068831743 type Work @default.
- W2068831743 sameAs 2068831743 @default.
- W2068831743 citedByCount "17" @default.
- W2068831743 countsByYear W20688317432012 @default.
- W2068831743 countsByYear W20688317432013 @default.
- W2068831743 countsByYear W20688317432014 @default.
- W2068831743 countsByYear W20688317432015 @default.
- W2068831743 countsByYear W20688317432016 @default.
- W2068831743 countsByYear W20688317432019 @default.
- W2068831743 countsByYear W20688317432022 @default.
- W2068831743 crossrefType "journal-article" @default.
- W2068831743 hasAuthorship W2068831743A5011624623 @default.
- W2068831743 hasAuthorship W2068831743A5024831387 @default.
- W2068831743 hasAuthorship W2068831743A5033640841 @default.
- W2068831743 hasAuthorship W2068831743A5040372679 @default.
- W2068831743 hasAuthorship W2068831743A5043539481 @default.
- W2068831743 hasAuthorship W2068831743A5055306078 @default.
- W2068831743 hasAuthorship W2068831743A5075769495 @default.
- W2068831743 hasAuthorship W2068831743A5089171427 @default.
- W2068831743 hasBestOaLocation W20688317431 @default.
- W2068831743 hasConcept C120197328 @default.
- W2068831743 hasConcept C121608353 @default.
- W2068831743 hasConcept C126322002 @default.
- W2068831743 hasConcept C142724271 @default.
- W2068831743 hasConcept C19431177 @default.
- W2068831743 hasConcept C204232928 @default.
- W2068831743 hasConcept C2776256026 @default.
- W2068831743 hasConcept C2781121885 @default.
- W2068831743 hasConcept C2781182431 @default.
- W2068831743 hasConcept C502942594 @default.
- W2068831743 hasConcept C529295009 @default.
- W2068831743 hasConcept C54355233 @default.
- W2068831743 hasConcept C555283112 @default.
- W2068831743 hasConcept C71924100 @default.
- W2068831743 hasConcept C81885089 @default.
- W2068831743 hasConcept C86803240 @default.
- W2068831743 hasConceptScore W2068831743C120197328 @default.
- W2068831743 hasConceptScore W2068831743C121608353 @default.
- W2068831743 hasConceptScore W2068831743C126322002 @default.
- W2068831743 hasConceptScore W2068831743C142724271 @default.
- W2068831743 hasConceptScore W2068831743C19431177 @default.
- W2068831743 hasConceptScore W2068831743C204232928 @default.
- W2068831743 hasConceptScore W2068831743C2776256026 @default.
- W2068831743 hasConceptScore W2068831743C2781121885 @default.
- W2068831743 hasConceptScore W2068831743C2781182431 @default.
- W2068831743 hasConceptScore W2068831743C502942594 @default.
- W2068831743 hasConceptScore W2068831743C529295009 @default.
- W2068831743 hasConceptScore W2068831743C54355233 @default.
- W2068831743 hasConceptScore W2068831743C555283112 @default.
- W2068831743 hasConceptScore W2068831743C71924100 @default.
- W2068831743 hasConceptScore W2068831743C81885089 @default.
- W2068831743 hasConceptScore W2068831743C86803240 @default.
- W2068831743 hasIssue "3" @default.
- W2068831743 hasLocation W20688317431 @default.
- W2068831743 hasLocation W20688317432 @default.
- W2068831743 hasOpenAccess W2068831743 @default.
- W2068831743 hasPrimaryLocation W20688317431 @default.
- W2068831743 hasRelatedWork W1554640292 @default.
- W2068831743 hasRelatedWork W2001238939 @default.
- W2068831743 hasRelatedWork W2022034062 @default.
- W2068831743 hasRelatedWork W2038766225 @default.
- W2068831743 hasRelatedWork W2092245381 @default.
- W2068831743 hasRelatedWork W2099334382 @default.
- W2068831743 hasRelatedWork W2122256734 @default.
- W2068831743 hasRelatedWork W2357981711 @default.
- W2068831743 hasRelatedWork W2472393267 @default.
- W2068831743 hasRelatedWork W4249511303 @default.
- W2068831743 hasVolume "45" @default.
- W2068831743 isParatext "false" @default.
- W2068831743 isRetracted "false" @default.
- W2068831743 magId "2068831743" @default.
- W2068831743 workType "article" @default.