FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068832387> ?p ?o ?g. }

• W2068832387 endingPage "63" @default.
• W2068832387 startingPage "54" @default.
• W2068832387 abstract "Conflicting results exist regarding the role of 5-HT3 receptors in somatic and visceral nociceptive processing. We aimed to investigate the effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Two injections (100 μl) of either pH 4.0 or 7.2 saline were given unilaterally in the gastrocnemius (GN) muscle. In all groups, the paw withdrawal thresholds (PWT) to von Frey filaments and the visceromotor responses (VMR) to colorectal distension (CRD) were recorded before the saline injections and 72 h, and 1 week after the second injection. Intrathecal (i.t.) (25 nmol) or intravenous (i.v.) (100 μg/kg/day) alosetron was given daily following the second injection and compared to either i.v. or i.t. saline (vehicle). There was a significant decrease in the mean PWT bilaterally in all groups following pH 4.0 injections (p < 0.05). Intravenous alosetron resulted in a significant increase in the PWT bilaterally on days 2 and 3. Intrathecal alosetron resulted in significant increase in the PWT starting at day 3 and was significantly higher than baseline on days 4–7 (p < 0.05). At CRD pressures ≥30 mmHg, the VMR of pH 4.0 injected rats was significantly increased at 72 h and 1 week (p < 0.05). Both i.v. and i.t. alosetron treated rats failed to demonstrate any alteration in the VMR. Control rats (pH 7.2) failed to show any alteration in the VMR and were unaffected by alosetron. Both, systemically and centrally administered alosetron, reversed the mechanical somatic hypersensitivity and prevented the development of visceral hyperalgesia, suggesting a centrally mediated effect." @default.
• W2068832387 created "2016-06-24" @default.
• W2068832387 creator A5007980005 @default.
• W2068832387 creator A5012432554 @default.
• W2068832387 creator A5056664985 @default.
• W2068832387 creator A5077509093 @default.
• W2068832387 date "2006-12-01" @default.
• W2068832387 modified "2023-10-17" @default.
• W2068832387 title "Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia" @default.
• W2068832387 cites W1968043085 @default.
• W2068832387 cites W1973736810 @default.
• W2068832387 cites W1975413521 @default.
• W2068832387 cites W1977682011 @default.
• W2068832387 cites W1982916178 @default.
• W2068832387 cites W1983249684 @default.
• W2068832387 cites W1983481999 @default.
• W2068832387 cites W1983587289 @default.
• W2068832387 cites W1986564836 @default.
• W2068832387 cites W1992466645 @default.
• W2068832387 cites W1994798728 @default.
• W2068832387 cites W1995604771 @default.
• W2068832387 cites W1999194329 @default.
• W2068832387 cites W2001658059 @default.
• W2068832387 cites W2007400870 @default.
• W2068832387 cites W2009246962 @default.
• W2068832387 cites W2010780461 @default.
• W2068832387 cites W2013632088 @default.
• W2068832387 cites W2018343808 @default.
• W2068832387 cites W2019674556 @default.
• W2068832387 cites W2026740933 @default.
• W2068832387 cites W2029389427 @default.
• W2068832387 cites W2042335480 @default.
• W2068832387 cites W2045898875 @default.
• W2068832387 cites W2046607147 @default.
• W2068832387 cites W2061114211 @default.
• W2068832387 cites W2061491246 @default.
• W2068832387 cites W2062700118 @default.
• W2068832387 cites W2067438641 @default.
• W2068832387 cites W2081401938 @default.
• W2068832387 cites W2081817123 @default.
• W2068832387 cites W2083910964 @default.
• W2068832387 cites W2089787597 @default.
• W2068832387 cites W2092667479 @default.
• W2068832387 cites W2126547777 @default.
• W2068832387 cites W2127837438 @default.
• W2068832387 cites W2132819503 @default.
• W2068832387 cites W2145549029 @default.
• W2068832387 cites W2154708260 @default.
• W2068832387 cites W2168107286 @default.
• W2068832387 cites W270465991 @default.
• W2068832387 cites W4240816745 @default.
• W2068832387 doi "https://doi.org/10.1016/j.pain.2006.06.014" @default.
• W2068832387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16844296" @default.
• W2068832387 hasPublicationYear "2006" @default.
• W2068832387 type Work @default.
• W2068832387 sameAs 2068832387 @default.
• W2068832387 citedByCount "38" @default.
• W2068832387 countsByYear W20688323872012 @default.
• W2068832387 countsByYear W20688323872013 @default.
• W2068832387 countsByYear W20688323872014 @default.
• W2068832387 countsByYear W20688323872015 @default.
• W2068832387 countsByYear W20688323872016 @default.
• W2068832387 countsByYear W20688323872017 @default.
• W2068832387 countsByYear W20688323872018 @default.
• W2068832387 countsByYear W20688323872019 @default.
• W2068832387 countsByYear W20688323872020 @default.
• W2068832387 countsByYear W20688323872021 @default.
• W2068832387 countsByYear W20688323872022 @default.
• W2068832387 countsByYear W20688323872023 @default.
• W2068832387 crossrefType "journal-article" @default.
• W2068832387 hasAuthorship W2068832387A5007980005 @default.
• W2068832387 hasAuthorship W2068832387A5012432554 @default.
• W2068832387 hasAuthorship W2068832387A5056664985 @default.
• W2068832387 hasAuthorship W2068832387A5077509093 @default.
• W2068832387 hasConcept C126322002 @default.
• W2068832387 hasConcept C134018914 @default.
• W2068832387 hasConcept C15490471 @default.
• W2068832387 hasConcept C170493617 @default.
• W2068832387 hasConcept C2776625112 @default.
• W2068832387 hasConcept C2776885963 @default.
• W2068832387 hasConcept C2777397205 @default.
• W2068832387 hasConcept C2778122271 @default.
• W2068832387 hasConcept C2779245659 @default.
• W2068832387 hasConcept C2779794527 @default.
• W2068832387 hasConcept C42219234 @default.
• W2068832387 hasConcept C71924100 @default.
• W2068832387 hasConceptScore W2068832387C126322002 @default.
• W2068832387 hasConceptScore W2068832387C134018914 @default.
• W2068832387 hasConceptScore W2068832387C15490471 @default.
• W2068832387 hasConceptScore W2068832387C170493617 @default.
• W2068832387 hasConceptScore W2068832387C2776625112 @default.
• W2068832387 hasConceptScore W2068832387C2776885963 @default.
• W2068832387 hasConceptScore W2068832387C2777397205 @default.
• W2068832387 hasConceptScore W2068832387C2778122271 @default.
• W2068832387 hasConceptScore W2068832387C2779245659 @default.
• W2068832387 hasConceptScore W2068832387C2779794527 @default.
• W2068832387 hasConceptScore W2068832387C42219234 @default.
• W2068832387 hasConceptScore W2068832387C71924100 @default.

• next