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• W2068836411 startingPage "647" @default.
• W2068836411 abstract "In teleosts, ovarian steroidogenesis is under the control of two gonadotropic hormones, GTH I and GTH II, that are structurally and functionally homologous to FSH and LH. The intracellular mechanisms by which GTH I and GTH II stimulate steroidogenesis in the teleost ovary are not well understood. The purpose of this study was to investigate the involvement of the cAMP/protein kinase A (PKA) and protein kinase C (PKC)/Ca 2+ signaling pathways in the steroidogenic actions of GTH I and GTH II in the ovary of the brook trout (Salvelinus fontinalis). The cAMP/PKA pathway mediated the actions of GTH I before germinal vesicle breakdown (preGVBD) and GTH II after GVBD and before ovulation (preOV). Experimental increases in intracellular cAMP concentration mimicked the steroidogenic effects of GTH I and GTH II, and an antagonistic analog of cAMP partially blocked them. In addition, GTH I and GTH II stimulated the production of cAMP in preGVBD and preOV follicles, respectively. Activation of the PKC/Ca2+ pathway by a phorbol ester or a Ca2+ ionophore blocked the GTH I- and GTH I-induced steroid production, whereas inhibition of PKC by specific inhibitors potentiated the effects of GTH I. These results suggest that the cAMP/PKA signaling pathway mediates the stimulatory effects of GTH I and GTH II on steroidogenesis, and they also suggest the additional involvement of the PKC/Ca2+ signaling pathway in modulating the actions of gonadotropins in brook trout ovarian follicles." @default.
• W2068836411 created "2016-06-24" @default.
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• W2068836411 date "1997-09-01" @default.
• W2068836411 modified "2023-09-27" @default.
• W2068836411 title "Stimulation of Brook Trout Ovarian Steroidogenesis by Gonadotropins I and II Is Mediated by the Cyclic Adenosine 3',5'-Monophosphate/Protein Kinase A Pathway1" @default.
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• W2068836411 doi "https://doi.org/10.1095/biolreprod57.3.647" @default.
• W2068836411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9283003" @default.
• W2068836411 hasPublicationYear "1997" @default.
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