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• W2068844851 abstract "Head size-, age- and gender-adjustment are inconsistently used in cross-sectional MRI studies. Assessment of these variables using specific techniques is required in large control datasets. This study assesses effects of head size (measured using total intracranial volume (TIV)), age and gender using region of interest (ROI) volumes, voxel-based morphometry (VBM) and cortical thickness in controls. Subjects included 42 women (mean age 58.6 years range 27-78) and 37 men (mean age 60.7 years range 24-81). Subjects were imaged on one scanner. TIV and whole-brain ROIs were measured semi-automatically. Lateral ventricle, hippocampus, amygdala, caudate and putamen volumes were generated using Freesurfer (4.1.0). VBM (SPM5 and DARTEL) and Freesurfer were used to assess effects within grey matter at each voxel and vertex respectively (FDR corrected, q<0.05). Linear regression was used to assess the individual and independent effects of gender, age and TIV. Age, gender, and TIV were individually associated with all ROI volumes (see table) except age and caudate, age and amygdala and gender and hippocampus. Age and TIV had independent associations with all ROIs. Gender had an independent effect only on whole brain (p<0.001). The 95% CIs of the slope of TIV and ROIs never contained 1 indicating that dividing by TIV is not appropriate head-size adjustment. Age had a widespread negative association with thickness and volume throughout the cortex which survived gender and TIV adjustment (see figure). TIV was associated with increased thickness in the right-sided occipital lobe but not after age and gender adjustment. TIV had a large positive association with grey matter volume, which remained following age and gender adjustment. Gender had some effect on thickness in the left hemisphere (women>men) and a large effect on volume (men>women) but these were lost following TIV and age adjustment. Age has a large effect on results generated by all analysis techniques. Head-size adjustment is unnecessary for thickness analysis should gender and age be used, but is required for volume analyses. Gender-adjustment may be necessary for thickness studies and some ROI analysis but not for VBM should TIV and age be used." @default.
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• W2068844851 date "2009-07-01" @default.
• W2068844851 modified "2023-09-26" @default.
• W2068844851 title "O2-01-06: Head size, age and gender adjustment in MRI studies: A necessary nuisance?" @default.
• W2068844851 doi "https://doi.org/10.1016/j.jalz.2009.05.321" @default.
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