FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068847044> ?p ?o ?g. }

• W2068847044 endingPage "341" @default.
• W2068847044 startingPage "337" @default.
• W2068847044 abstract "Dextromethorphan is an N ‐methyl‐ d ‐aspartate (NMDA) noncompetitive antagonist which has been used as an antitussive, analgesic adjunct, probe drug, experimentally to attenuate acute opiate and ethanol withdrawal, and as an anticonvulsant. A metabolite of dextromethorphan, dextrorphan, has been shown to behave pharmacodynamically in a similar manner to dextromethorphan. The pharmacokinetics of dextromethorphan were examined in six healthy dogs following intravenous (2.2 mg/kg) and oral (5 mg/kg) administration in a randomized crossover design. Dextromethorphan behaved in a similar manner to other NMDA antagonists upon injection causing muscle rigidity, ataxia to recumbency, sedation, urination, and ptyalism which resolved within 90 min. One dog repeatedly vomited upon oral administration and was excluded from oral analysis. Mean ± SD values for half‐life, apparent volume of distribution, and clearance after i.v. administration were 2.0 ±0.6 h, 5.1 ± 2.6 L/kg, and 33.8 ± 16.5 mL/min/kg. Oral bioavailability was 11% as calculated from naïve pooled data. Free dextrorphan was not detected in any plasma sample, however enzymatic treatment of plasma with glucuronidase released both dextromethorphan and dextrorphan indicating that conjugation is a metabolic route. The short half‐life, rapid clearance, and poor bioavailability of dextromethorphan limit its potential use as a chronic orally administered therapeutic." @default.
• W2068847044 created "2016-06-24" @default.
• W2068847044 creator A5001993864 @default.
• W2068847044 creator A5016943199 @default.
• W2068847044 date "2004-10-01" @default.
• W2068847044 modified "2023-10-18" @default.
• W2068847044 title "Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs" @default.
• W2068847044 cites W152943885 @default.
• W2068847044 cites W1601438838 @default.
• W2068847044 cites W1795574849 @default.
• W2068847044 cites W1968666033 @default.
• W2068847044 cites W1970412199 @default.
• W2068847044 cites W1984999195 @default.
• W2068847044 cites W1986631486 @default.
• W2068847044 cites W2003798699 @default.
• W2068847044 cites W2005227694 @default.
• W2068847044 cites W2014103157 @default.
• W2068847044 cites W2016749647 @default.
• W2068847044 cites W2017656271 @default.
• W2068847044 cites W2027139424 @default.
• W2068847044 cites W2027988135 @default.
• W2068847044 cites W2035487071 @default.
• W2068847044 cites W2035494757 @default.
• W2068847044 cites W2040038240 @default.
• W2068847044 cites W2064986719 @default.
• W2068847044 cites W2068620566 @default.
• W2068847044 cites W2074319544 @default.
• W2068847044 cites W2075704939 @default.
• W2068847044 cites W2088302234 @default.
• W2068847044 cites W2089192919 @default.
• W2068847044 cites W2092931379 @default.
• W2068847044 cites W2160609349 @default.
• W2068847044 cites W2502670554 @default.
• W2068847044 cites W4232243248 @default.
• W2068847044 cites W4243442125 @default.
• W2068847044 doi "https://doi.org/10.1111/j.1365-2885.2004.00608.x" @default.
• W2068847044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15500572" @default.
• W2068847044 hasPublicationYear "2004" @default.
• W2068847044 type Work @default.
• W2068847044 sameAs 2068847044 @default.
• W2068847044 citedByCount "31" @default.
• W2068847044 countsByYear W20688470442012 @default.
• W2068847044 countsByYear W20688470442013 @default.
• W2068847044 countsByYear W20688470442014 @default.
• W2068847044 countsByYear W20688470442015 @default.
• W2068847044 countsByYear W20688470442016 @default.
• W2068847044 countsByYear W20688470442017 @default.
• W2068847044 countsByYear W20688470442019 @default.
• W2068847044 countsByYear W20688470442020 @default.
• W2068847044 countsByYear W20688470442021 @default.
• W2068847044 countsByYear W20688470442022 @default.
• W2068847044 countsByYear W20688470442023 @default.
• W2068847044 crossrefType "journal-article" @default.
• W2068847044 hasAuthorship W2068847044A5001993864 @default.
• W2068847044 hasAuthorship W2068847044A5016943199 @default.
• W2068847044 hasConcept C112705442 @default.
• W2068847044 hasConcept C126322002 @default.
• W2068847044 hasConcept C139254425 @default.
• W2068847044 hasConcept C142724271 @default.
• W2068847044 hasConcept C149151106 @default.
• W2068847044 hasConcept C181389837 @default.
• W2068847044 hasConcept C185592680 @default.
• W2068847044 hasConcept C204787440 @default.
• W2068847044 hasConcept C27081682 @default.
• W2068847044 hasConcept C2777056448 @default.
• W2068847044 hasConcept C2777477808 @default.
• W2068847044 hasConcept C2779591118 @default.
• W2068847044 hasConcept C2781245242 @default.
• W2068847044 hasConcept C42219234 @default.
• W2068847044 hasConcept C71924100 @default.
• W2068847044 hasConcept C87813604 @default.
• W2068847044 hasConcept C98274493 @default.
• W2068847044 hasConceptScore W2068847044C112705442 @default.
• W2068847044 hasConceptScore W2068847044C126322002 @default.
• W2068847044 hasConceptScore W2068847044C139254425 @default.
• W2068847044 hasConceptScore W2068847044C142724271 @default.
• W2068847044 hasConceptScore W2068847044C149151106 @default.
• W2068847044 hasConceptScore W2068847044C181389837 @default.
• W2068847044 hasConceptScore W2068847044C185592680 @default.
• W2068847044 hasConceptScore W2068847044C204787440 @default.
• W2068847044 hasConceptScore W2068847044C27081682 @default.
• W2068847044 hasConceptScore W2068847044C2777056448 @default.
• W2068847044 hasConceptScore W2068847044C2777477808 @default.
• W2068847044 hasConceptScore W2068847044C2779591118 @default.
• W2068847044 hasConceptScore W2068847044C2781245242 @default.
• W2068847044 hasConceptScore W2068847044C42219234 @default.
• W2068847044 hasConceptScore W2068847044C71924100 @default.
• W2068847044 hasConceptScore W2068847044C87813604 @default.
• W2068847044 hasConceptScore W2068847044C98274493 @default.
• W2068847044 hasIssue "5" @default.
• W2068847044 hasLocation W20688470441 @default.
• W2068847044 hasLocation W20688470442 @default.
• W2068847044 hasOpenAccess W2068847044 @default.
• W2068847044 hasPrimaryLocation W20688470441 @default.
• W2068847044 hasRelatedWork W128878117 @default.
• W2068847044 hasRelatedWork W1972083277 @default.
• W2068847044 hasRelatedWork W2007801356 @default.
• W2068847044 hasRelatedWork W2027731572 @default.

• next