FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068848135> ?p ?o ?g. }

• W2068848135 endingPage "352" @default.
• W2068848135 startingPage "339" @default.
• W2068848135 abstract "Triggering receptor expressed on myeloid cells 1 (TREM-1) is an important mediator of innate inflammatory responses in microbial infections and sepsis. TREM-1 ligation on neutrophils (PMN) or monocytes results in the production of proinflammatory cytokines. Engagement of TREM-1 induces the activation of MAP kinases as well as rapid Ca(2+) mobilization. However, a detailed understanding of TREM-1 signaling pathways is currently lacking. We evaluated the TREM-1 signaling hierarchy in monocytic cells and found that the acute myeloid leukemia cell line MUTZ-3 expresses TREM-1 in a natural and functional manner. We compared essential signaling molecules of the TREM-1, TLR and NLR cascade in MUTZ-3 cells as well as primary monocytes or PMN by Western blot analysis. These studies confirmed the essential role of phosphatidyl inositide 3-kinase (PI3K) and p38MAPK in the TREM-1 as well as the TLR or NLR cascade of monocytic cells. Importantly, PI3K and p38MAPK signals in monocytic cells both control Ca(2+) mobilization and are directly connected in the TREM-1 signaling hierarchy, which contrasts previous results obtained in PMN. Taken together, our results indicate cell type-specific differences in the TREM-1 signaling cascade and contribute to an enhanced understanding of the regulation of innate inflammatory responses." @default.
• W2068848135 created "2016-06-24" @default.
• W2068848135 creator A5007309983 @default.
• W2068848135 creator A5023228789 @default.
• W2068848135 creator A5030598868 @default.
• W2068848135 creator A5034980594 @default.
• W2068848135 creator A5045756025 @default.
• W2068848135 creator A5074197659 @default.
• W2068848135 creator A5077343998 @default.
• W2068848135 creator A5080494639 @default.
• W2068848135 creator A5083864022 @default.
• W2068848135 date "2013-11-21" @default.
• W2068848135 modified "2023-10-16" @default.
• W2068848135 title "Distinct Signaling Cascades of TREM-1, TLR and NLR in Neutrophils and Monocytic Cells" @default.
• W2068848135 cites W1643888758 @default.
• W2068848135 cites W1982645038 @default.
• W2068848135 cites W1986899130 @default.
• W2068848135 cites W1992044675 @default.
• W2068848135 cites W2004078164 @default.
• W2068848135 cites W2005287515 @default.
• W2068848135 cites W2008338946 @default.
• W2068848135 cites W2016943745 @default.
• W2068848135 cites W2019558661 @default.
• W2068848135 cites W2023472659 @default.
• W2068848135 cites W2028432878 @default.
• W2068848135 cites W2042849317 @default.
• W2068848135 cites W2044868069 @default.
• W2068848135 cites W2047796994 @default.
• W2068848135 cites W2048339949 @default.
• W2068848135 cites W2050251284 @default.
• W2068848135 cites W2056047308 @default.
• W2068848135 cites W2060705550 @default.
• W2068848135 cites W2064346335 @default.
• W2068848135 cites W2085217889 @default.
• W2068848135 cites W2086964969 @default.
• W2068848135 cites W2092035190 @default.
• W2068848135 cites W2099204219 @default.
• W2068848135 cites W2110564533 @default.
• W2068848135 cites W2125100264 @default.
• W2068848135 cites W2128413447 @default.
• W2068848135 cites W2132718517 @default.
• W2068848135 cites W2144728423 @default.
• W2068848135 cites W2146857507 @default.
• W2068848135 cites W2150747928 @default.
• W2068848135 cites W2155533398 @default.
• W2068848135 cites W2158062242 @default.
• W2068848135 cites W2162885959 @default.
• W2068848135 cites W2164235155 @default.
• W2068848135 doi "https://doi.org/10.1159/000355892" @default.
• W2068848135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6741579" @default.
• W2068848135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24281714" @default.
• W2068848135 hasPublicationYear "2013" @default.
• W2068848135 type Work @default.
• W2068848135 sameAs 2068848135 @default.
• W2068848135 citedByCount "25" @default.
• W2068848135 countsByYear W20688481352014 @default.
• W2068848135 countsByYear W20688481352015 @default.
• W2068848135 countsByYear W20688481352016 @default.
• W2068848135 countsByYear W20688481352017 @default.
• W2068848135 countsByYear W20688481352018 @default.
• W2068848135 countsByYear W20688481352019 @default.
• W2068848135 countsByYear W20688481352020 @default.
• W2068848135 countsByYear W20688481352021 @default.
• W2068848135 countsByYear W20688481352022 @default.
• W2068848135 countsByYear W20688481352023 @default.
• W2068848135 crossrefType "journal-article" @default.
• W2068848135 hasAuthorship W2068848135A5007309983 @default.
• W2068848135 hasAuthorship W2068848135A5023228789 @default.
• W2068848135 hasAuthorship W2068848135A5030598868 @default.
• W2068848135 hasAuthorship W2068848135A5034980594 @default.
• W2068848135 hasAuthorship W2068848135A5045756025 @default.
• W2068848135 hasAuthorship W2068848135A5074197659 @default.
• W2068848135 hasAuthorship W2068848135A5077343998 @default.
• W2068848135 hasAuthorship W2068848135A5080494639 @default.
• W2068848135 hasAuthorship W2068848135A5083864022 @default.
• W2068848135 hasBestOaLocation W20688481351 @default.
• W2068848135 hasConcept C136449434 @default.
• W2068848135 hasConcept C164027704 @default.
• W2068848135 hasConcept C170493617 @default.
• W2068848135 hasConcept C185592680 @default.
• W2068848135 hasConcept C203014093 @default.
• W2068848135 hasConcept C204258353 @default.
• W2068848135 hasConcept C2776170302 @default.
• W2068848135 hasConcept C2776914184 @default.
• W2068848135 hasConcept C2778461978 @default.
• W2068848135 hasConcept C2780943621 @default.
• W2068848135 hasConcept C54166955 @default.
• W2068848135 hasConcept C54355233 @default.
• W2068848135 hasConcept C55493867 @default.
• W2068848135 hasConcept C62478195 @default.
• W2068848135 hasConcept C81885089 @default.
• W2068848135 hasConcept C86554907 @default.
• W2068848135 hasConcept C86803240 @default.
• W2068848135 hasConcept C95444343 @default.
• W2068848135 hasConceptScore W2068848135C136449434 @default.
• W2068848135 hasConceptScore W2068848135C164027704 @default.
• W2068848135 hasConceptScore W2068848135C170493617 @default.
• W2068848135 hasConceptScore W2068848135C185592680 @default.

• next