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- W2068851741 abstract "We have used chemical protein synthesis and advanced physical methods to probe dynamics-function correlations for the HIV-1 protease, an enzyme that has received considerable attention as a target for the treatment of AIDS. Chemical synthesis was used to prepare a series of unique analogues of the HIV-1 protease in which the flexibility of the “flap” structures (residues 37–61 in each monomer of the homodimeric protein molecule) was systematically varied. These analogue enzymes were further studied by X-ray crystallography, NMR relaxation, and pulse-EPR methods, in conjunction with molecular dynamics simulations. We show that conformational isomerization in the flaps is correlated with structural reorganization of residues in the active site, and that it is preorganization of the active site that is a rate-limiting factor in catalysis." @default.
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- W2068851741 date "2011-12-08" @default.
- W2068851741 modified "2023-09-25" @default.
- W2068851741 title "Protein conformational dynamics in the mechanism of HIV-1 protease catalysis" @default.
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- W2068851741 doi "https://doi.org/10.1073/pnas.1111202108" @default.
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