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• W2068851962 abstract "A novel synthetic hexapeptide (SFKLRY-NH(2)) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). The peptide induced proliferation, migration, and capillary-like tube formation in primary cultured HUVECs, and augmented vessel sprouting ex vivo while attenuated by the treatment with pertussis toxin (PTX) or U73122 (PLC-inhibitor) suggesting the influence of PTX-sensitive G-proteins and PLC. In addition, SFKLRY-NH(2) up-regulated the expression of VEGF-A in HUVECs and the neutralizing antibody against VEGF suppressed SFKLRY-NH(2)-induced tube formation activity. Taken together, these results suggest that SFKLRY-NH(2) may induce blood vessel formation by PTX-sensitive G protein-coupled receptor-PLC-Ca(2+) signaling cascade leading into VEGF-A expression in HUVECs." @default.
• W2068851962 created "2016-06-24" @default.
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• W2068851962 date "2009-02-01" @default.
• W2068851962 modified "2023-09-26" @default.
• W2068851962 title "Identification of novel synthetic peptide showing angiogenic activity in human endothelial cells" @default.
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• W2068851962 doi "https://doi.org/10.1016/j.peptides.2008.10.003" @default.
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