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- W2068852761 abstract "Abstract The determinants of charge selectivity of the Cys‐loop family of ligand‐gated ion channels have been studied for more than a decade. The investigations have mainly covered homomeric receptors e.g. the nicotinic acetylcholine receptor α 7 , the glycine receptor α 1 and the serotonin receptor 5‐HT 3A . Only recently, the determinants of charge selectivity of heteromeric receptors have been addressed for the GABA A receptor α 2 β 3 γ 2 . For all receptor subtypes, the selectivity determinants have been located to an intracellular linker between transmembrane domains M1 and M2. Two features of the M1–M2 linker appear to control ion selectivity. A central role for charged amino acid residues in selectivity has been almost universally observed. Furthermore, recent studies point to an important role of the size of the narrowest constriction in the pore. In the present review, these determinants of charge selectivity of the Cys‐loop family of ligand‐gated ion channels will be discussed in detail." @default.
- W2068852761 created "2016-06-24" @default.
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- W2068852761 date "2004-12-17" @default.
- W2068852761 modified "2023-10-16" @default.
- W2068852761 title "Charge selectivity of the Cys-loop family of ligand-gated ion channels" @default.
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- W2068852761 doi "https://doi.org/10.1111/j.1471-4159.2004.02883.x" @default.
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