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• W2068854551 abstract "Nuclear factor kappa B (NF-kappaB) transcription factors regulate several important physiological processes, including inflammation and immune responses, cell growth, apoptosis, and the expression of certain viral genes. Therefore, the NF-kappaB signaling pathway has also provided a focus for pharmacological intervention, primarily in situations of chronic inflammation or in cancer, where the pathway is often constitutively active and plays a key role in the disease. Now that many of the molecular details of the NF-kappaB pathway are known, it is clear that modulators of this pathway can act at several levels. As described herein, over 750 inhibitors of the NF-kappaB pathway have been identified, including a variety of natural and synthetic molecules. These compounds include antioxidants, peptides, small RNA/DNA, microbial and viral proteins, small molecules, and engineered dominant-negative or constitutively active polypeptides. Several of these molecules act as general inhibitors of NF-kappaB induction, whereas others inhibit specific pathways of induction. In addition, some compounds appear to target multiple steps in the NF-kappaB pathway. Compounds designed as specific NF-kappaB inhibitors are not yet in clinical use, but they are likely to be developed as treatments for certain cancers and neurodegenerative and inflammatory diseases. Moreover, the therapeutic and preventative effects of many natural products may, at least in part, be due to their ability to inhibit NF-kappaB." @default.
• W2068854551 created "2016-06-24" @default.
• W2068854551 creator A5040361007 @default.
• W2068854551 creator A5042073445 @default.
• W2068854551 date "2006-10-30" @default.
• W2068854551 modified "2023-10-10" @default.
• W2068854551 title "Inhibitors of NF-κB signaling: 785 and counting" @default.
• W2068854551 cites W1133745686 @default.
• W2068854551 cites W1492606093 @default.
• W2068854551 cites W1506034405 @default.
• W2068854551 cites W1513349945 @default.
• W2068854551 cites W1534895763 @default.
• W2068854551 cites W1542493247 @default.
• W2068854551 cites W1547652970 @default.
• W2068854551 cites W1558367558 @default.
• W2068854551 cites W1570159053 @default.
• W2068854551 cites W157084603 @default.
• W2068854551 cites W1581923494 @default.
• W2068854551 cites W1605767786 @default.
• W2068854551 cites W1624615502 @default.
• W2068854551 cites W1754199354 @default.
• W2068854551 cites W1759028523 @default.
• W2068854551 cites W184020152 @default.
• W2068854551 cites W1881072801 @default.
• W2068854551 cites W1949250048 @default.
• W2068854551 cites W1963906419 @default.
• W2068854551 cites W1965459549 @default.
• W2068854551 cites W1965583590 @default.
• W2068854551 cites W1965755283 @default.
• W2068854551 cites W1966923590 @default.
• W2068854551 cites W1966995589 @default.
• W2068854551 cites W1967964903 @default.
• W2068854551 cites W1968149558 @default.
• W2068854551 cites W1969929211 @default.
• W2068854551 cites W1970613606 @default.
• W2068854551 cites W1973060929 @default.
• W2068854551 cites W1974528343 @default.
• W2068854551 cites W1977915168 @default.
• W2068854551 cites W1977951553 @default.
• W2068854551 cites W1979520552 @default.
• W2068854551 cites W1980768491 @default.
• W2068854551 cites W1980902026 @default.
• W2068854551 cites W1985275612 @default.
• W2068854551 cites W1986663284 @default.
• W2068854551 cites W1988623172 @default.
• W2068854551 cites W1991743392 @default.
• W2068854551 cites W1991785898 @default.
• W2068854551 cites W1992458525 @default.
• W2068854551 cites W1994412772 @default.
• W2068854551 cites W1996128391 @default.
• W2068854551 cites W1997509253 @default.
• W2068854551 cites W1997842448 @default.
• W2068854551 cites W1999177172 @default.
• W2068854551 cites W1999982643 @default.
• W2068854551 cites W2006720157 @default.
• W2068854551 cites W2010237936 @default.
• W2068854551 cites W2011728703 @default.
• W2068854551 cites W2012378866 @default.
• W2068854551 cites W2015516607 @default.
• W2068854551 cites W2016216633 @default.
• W2068854551 cites W2018554367 @default.
• W2068854551 cites W2021173092 @default.
• W2068854551 cites W2023024698 @default.
• W2068854551 cites W2023508382 @default.
• W2068854551 cites W2024964682 @default.
• W2068854551 cites W2027667241 @default.
• W2068854551 cites W2027835440 @default.
• W2068854551 cites W2028201227 @default.
• W2068854551 cites W2030213143 @default.
• W2068854551 cites W2030592815 @default.
• W2068854551 cites W2031433004 @default.
• W2068854551 cites W2031637294 @default.
• W2068854551 cites W2032401957 @default.
• W2068854551 cites W2032514624 @default.
• W2068854551 cites W2035088045 @default.
• W2068854551 cites W2037283275 @default.
• W2068854551 cites W2037952169 @default.
• W2068854551 cites W2039170092 @default.
• W2068854551 cites W2040025789 @default.
• W2068854551 cites W2041186477 @default.
• W2068854551 cites W2042709514 @default.
• W2068854551 cites W2043342443 @default.
• W2068854551 cites W2043892945 @default.
• W2068854551 cites W2044608904 @default.
• W2068854551 cites W2051049915 @default.
• W2068854551 cites W2053618292 @default.
• W2068854551 cites W2056831005 @default.
• W2068854551 cites W2057543839 @default.
• W2068854551 cites W2058593051 @default.
• W2068854551 cites W2059570070 @default.
• W2068854551 cites W2059958540 @default.
• W2068854551 cites W2060110412 @default.
• W2068854551 cites W2060987284 @default.
• W2068854551 cites W2061726942 @default.
• W2068854551 cites W2062368346 @default.
• W2068854551 cites W2062711706 @default.
• W2068854551 cites W2062886087 @default.
• W2068854551 cites W2064055597 @default.

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