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- W2068854558 abstract "α,β-Unsaturated chiral oxazolidinone 10 can be smoothly obtained from the corresponding aldehyde 14 under Masamune-Roush conditions. Oxazolidinone 10 reacts diastereoselectively with diene 14 under lewis acid catalysis which allows the synthesis of 3,4-substituted cyclohexanone 16 and its derivatives 20, 21, and 22 in good overall yields from ester 4. These compounds can be converted to the corresponding hydroxyethylamine derivatives, analogues of Saquinavir 1, which are known to have antiviral activity." @default.
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- W2068854558 date "2004-01-01" @default.
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- W2068854558 title "HIV Protease Inhibitor Part 1: Use of Evans’ Oxazolidinone in Intermolecular Diels-Alder Reaction en route to 3,4-Substituted Cyclohexanones" @default.
- W2068854558 doi "https://doi.org/10.1055/s-2004-815438" @default.
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