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• W2068858970 abstract "Abstract The purpose of this study was to characterize the physicochemical properties of calcific deposits that cause the failure of tissue‐derived heart valve bioprostheses. This was done in an effort to understand the mechanism of pathologic biomineralization in the cardiovascular system and potentially prevent deterioration of bioprostheses. Calcific deposits taken from 10 failed bioprosthetic valves that had been implanted in patients for 2–13 years were characterized by chemical analysis, x‐ray diffraction, FTIR spectroscopy, scanning electron microscopy, polarized light microscopy, and solubility measurements. The combined results identified the biomineral as an apatitic calcium phosphate salt with substantial incorporation of sodium, magnesium and carbonate. The average Ca/PO 4 ratio for this “young” pathologic biomineral was ∼1.3, considerably lower than ∼1.7 found in mature atherosclerotic plaque biomineral and mature skeletal biomineral, both of which approximate hydroxyapatite in composition. Deproteinated calcific deposits from bioprostheses had thermodynamic solubilities comparable to those of both atherosclerotic plaque, typical pathologic biomineral and hydrolyzed octacalcium phosphate (OCP, Ca 4 H(PO 4 ) 3 · 2.5 H 2 O), a proposed precursor phase to biomineral apatite. This later finding, together with chemical composition and structrual details of the bioprostetic deposits themselves, supports a mechanism of cardiovascular calcification in which OCP plays a crucial role in the formation of the final apatitic phase. This suggests an approach toward prevention of bioprosthetic tissue calcification through control of the formation of the kinetically favored OCP precursor and/or its transformation into bioapatite. © 1994 John Wiley & Sons, Inc. This article is a U.S. Government work and, as such, is in the public domain in the United States of America." @default.
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• W2068858970 date "1994-01-01" @default.
• W2068858970 modified "2023-10-17" @default.
• W2068858970 title "Physicochemical properties of calcific deposits isolated from porcine bioprosthetic heart valves removed from patients following 2–13 years function" @default.
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• W2068858970 doi "https://doi.org/10.1002/jbm.820280106" @default.
• W2068858970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8126027" @default.
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