Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068859048> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2068859048 endingPage "461" @default.
- W2068859048 startingPage "453" @default.
- W2068859048 abstract "The nature of protein modifications, particularly surface glycosylation, in Plasmodium falciparum has long been observed, but in recent times controversial reports appeared. It is considered that the surface modifications, O- and N-glycosylation, have been of particular importance to the malarial parasite itself as well as to the erythrocyte. The modifications in the erythrocytic membranes and changes in the parasitic structure have been the subject of intense investigations in recent years. Comprehensive elaborations resulted in the development of means to describe the extensively modified structural and antigenic properties of the host cell and parasitic molecules that are of vital significance in the understanding of the functions of biologically important molecules such as the merozoite surface protein-1 (MSP-1). A combinatorial behavior of the parasitic and host cell molecules becomes the basis for molecular modifications of the parasite proteins and the events leading to invasion and survival of the parasite. The MSP-1 protein is modified on the surface by a sugar moiety O-glycosidically linked in β-configuration. This β-O-GlcNAc modication of MSP-1 has been predicted by computer assistance and experimentally verified. The Plasmodium falciparum proteins are known to be phosphorylated, and phosphorylation of MSP-1 has been predicted; moreover, there is sufficient experimental evidence to suggest phosphorylation. Computer assisted studies suggest a strong possibility of interplay between glycosylation and phosphorylation in proteins with β-O-GlcNAc modification. Keywords: falciparum, proteins, merozoite" @default.
- W2068859048 created "2016-06-24" @default.
- W2068859048 creator A5002696404 @default.
- W2068859048 creator A5047896581 @default.
- W2068859048 creator A5072006315 @default.
- W2068859048 creator A5079842074 @default.
- W2068859048 date "2004-03-01" @default.
- W2068859048 modified "2023-09-26" @default.
- W2068859048 title "Combinatorial Metabolism in Plasmodium falciparum-Infected Erythrocyte and Interplay of Glycosylation & Phosphorylation" @default.
- W2068859048 doi "https://doi.org/10.2174/1385272043485855" @default.
- W2068859048 hasPublicationYear "2004" @default.
- W2068859048 type Work @default.
- W2068859048 sameAs 2068859048 @default.
- W2068859048 citedByCount "1" @default.
- W2068859048 crossrefType "journal-article" @default.
- W2068859048 hasAuthorship W2068859048A5002696404 @default.
- W2068859048 hasAuthorship W2068859048A5047896581 @default.
- W2068859048 hasAuthorship W2068859048A5072006315 @default.
- W2068859048 hasAuthorship W2068859048A5079842074 @default.
- W2068859048 hasConcept C108625454 @default.
- W2068859048 hasConcept C11960822 @default.
- W2068859048 hasConcept C136764020 @default.
- W2068859048 hasConcept C14036430 @default.
- W2068859048 hasConcept C185592680 @default.
- W2068859048 hasConcept C203014093 @default.
- W2068859048 hasConcept C2777313579 @default.
- W2068859048 hasConcept C2778048844 @default.
- W2068859048 hasConcept C2778371730 @default.
- W2068859048 hasConcept C2778675580 @default.
- W2068859048 hasConcept C41008148 @default.
- W2068859048 hasConcept C55493867 @default.
- W2068859048 hasConcept C71928629 @default.
- W2068859048 hasConcept C86803240 @default.
- W2068859048 hasConcept C95444343 @default.
- W2068859048 hasConceptScore W2068859048C108625454 @default.
- W2068859048 hasConceptScore W2068859048C11960822 @default.
- W2068859048 hasConceptScore W2068859048C136764020 @default.
- W2068859048 hasConceptScore W2068859048C14036430 @default.
- W2068859048 hasConceptScore W2068859048C185592680 @default.
- W2068859048 hasConceptScore W2068859048C203014093 @default.
- W2068859048 hasConceptScore W2068859048C2777313579 @default.
- W2068859048 hasConceptScore W2068859048C2778048844 @default.
- W2068859048 hasConceptScore W2068859048C2778371730 @default.
- W2068859048 hasConceptScore W2068859048C2778675580 @default.
- W2068859048 hasConceptScore W2068859048C41008148 @default.
- W2068859048 hasConceptScore W2068859048C55493867 @default.
- W2068859048 hasConceptScore W2068859048C71928629 @default.
- W2068859048 hasConceptScore W2068859048C86803240 @default.
- W2068859048 hasConceptScore W2068859048C95444343 @default.
- W2068859048 hasIssue "5" @default.
- W2068859048 hasLocation W20688590481 @default.
- W2068859048 hasOpenAccess W2068859048 @default.
- W2068859048 hasPrimaryLocation W20688590481 @default.
- W2068859048 hasRelatedWork W1497193691 @default.
- W2068859048 hasRelatedWork W1749420422 @default.
- W2068859048 hasRelatedWork W1919813534 @default.
- W2068859048 hasRelatedWork W2014726229 @default.
- W2068859048 hasRelatedWork W2028735108 @default.
- W2068859048 hasRelatedWork W2040556830 @default.
- W2068859048 hasRelatedWork W2086777652 @default.
- W2068859048 hasRelatedWork W2118002029 @default.
- W2068859048 hasRelatedWork W2399376286 @default.
- W2068859048 hasRelatedWork W2725507533 @default.
- W2068859048 hasVolume "8" @default.
- W2068859048 isParatext "false" @default.
- W2068859048 isRetracted "false" @default.
- W2068859048 magId "2068859048" @default.
- W2068859048 workType "article" @default.