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• W2068873169 abstract "Palladium and platinum complexes with HmtpO (where HmtpO = 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine, an analogue of the natural ocurring nucleobase hypoxanthine) of the types [M(dmba)(PPh3)(HmtpO)]ClO4 [dmba = N,C-chelating 2-(dimethylaminomethyl)phenyl; M = Pd or Pt], [Pd(N−N)(C6F5)(HmtpO)]ClO4 [N-N = 2,2′-bipyridine (bpy), 4,4′-dimethyl-2,2′-bipyridine (Me2bpy), or N,N,N′,N′-tetramethylethylenediamine (tmeda)] and cis-[M(C6F5)2(HmtpO)2] (M = Pd or Pt) (head-to-head atropisomer in the solid state) have been obtained. Pd(II) and Pt(II) complexes with the anion of HmtpO of the types [Pd(tmeda)(C6F5)(mtpO)], [Pd(dmba)(µ-mtpO)]2, and [NBu4]2[M(C6F5)2(µ-mtpO)]2 (M = Pd or Pt) have been prepared starting from the corresponding hydroxometal complexes. Complexes containing simultaneously both the neutral HmtpO ligand and the anionic mtpO of the type [NBu4][M(C6F5)2(HmtpO)(mtpO)] (M = Pd or Pt) have been also obtained. In these mtpO−HmtpO metal complexes, for the first time, prototropic exchange is observed between the two heterocyclic ligands. The crystal structures of [Pd(dmba)(PPh3)(HmtpO)]+, cis-[Pt(C6F5)2(HmtpO)2]·acetone, [Pd(C6F5)(tmeda)(mtpO)]·2H2O, [Pd(dmba)(µ-mtpO)]2, [NBu4]2[Pd(C6F5)2(µ-mtpO)]2·CH2Cl2·toluene, [NBu4]2[Pt(C6F5)2(µ-mtpO)]2·0.5(toluene), and [NBu4][Pt(C6F5)2(mtpO)(HmtpO)] have been established by X-ray diffraction. Values of IC50 were calculated for the new platinum complexes cis-[Pt(C6F5)2(HmtpO)2] and [Pt(dmba)(PPh3)(HmtpO)]ClO4 against a panel of human tumor cell lines representative of ovarian (A2780 and A2780cisR), lung (NCI-H460), and breast cancers (T47D). At 48 h incubation time, both complexes were about 8-fold more active than cisplatin in T47D and show very low resistance factors against an A2780 cell line, which has acquired resistance to cisplatin. The DNA adduct formation of cis-[Pt(C6F5)2(HmtpO)2] and [Pt(dmba)(PPh3)(HmtpO)]ClO4 was followed by circular dichroism and electrophoretic mobility. Atomic force microscopy images of the modifications caused by these platinum complexes on plasmid DNA pBR322 were also obtained." @default.
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• W2068873169 date "2008-04-30" @default.
• W2068873169 modified "2023-10-18" @default.
• W2068873169 title "Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-<i>a</i>]pyrimidine. Antitumor Activity of the Platinum Compounds" @default.
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• W2068873169 doi "https://doi.org/10.1021/ic701873b" @default.
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