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- W2068874029 abstract "Dynamin is a master regulator of membrane fission in endocytosis. However, a function for dynamin immediately upon fusion has also been suspected from a variety of experiments that measured release of granule contents. The role of the dynamin GTPase activity in controlling fusion pore expansion and post-fusion granule membrane topology was investigated using the powerful membrane curvature-imaging technique of polarized TIRF microscopy and amperometry. A dynamin-1 mutant with increased GTPase activity resulted in faster fusion pore widening and flattening of the granule membrane after exocytosis; dynamin-1 mutants with decreased activity slowed fusion pore widening by stabilizing post-fusion granule membrane curvature. The experiments indicate that the GTPase activity of dynamin functions as a timer determining the rapidity of fusion pore expansion from 10's of milliseconds to seconds after fusion, in addition to its role in endocytosis. These findings expand the membrane-sculpting repertoire of dynamin to include the regulation of immediate post-fusion events in exocytosis that control the rate of release of soluble granule contents." @default.
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- W2068874029 date "2011-02-01" @default.
- W2068874029 modified "2023-09-29" @default.
- W2068874029 title "A new Role for the Dynamin Gtpase as a timer that Controls Fusion Pore Expansion" @default.
- W2068874029 doi "https://doi.org/10.1016/j.bpj.2010.12.370" @default.
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