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- W2068874892 abstract "Abstract The effects of three myasthenia drugs on activities of ACh-esterase and ACh-receptor were determined in a membrane preparation of Torpedo electroplax. The hydrolysis of ACh by ACh-esterase was inhibited competitively by neostigmine and pyridostigmine, with the former being the most effective. There was general agreement between the relative affinities of these drugs and their effectiveness in treatment of myasthenia, which points to the usefulness of this membrane preparation for preclinical screening of myasthenia drugs. Edrophonium inhibited ACh-esterase in a mixed competitive-noncompetitive manner, and exhibited an unexpectedly high affinity for the ACh-receptor, only 2.6-fold lower than its affinity for ACh-esterase. It is suggested that, at the dose used in myasthenia, edrophonium acts as an in vivo activator of the ACh-receptor." @default.
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- W2068874892 date "1974-07-01" @default.
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- W2068874892 title "Affinity of myasthenia drugs to acetylcholinesterase and acetylcholine receptor" @default.
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- W2068874892 doi "https://doi.org/10.1016/0006-2944(74)90029-5" @default.
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