Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068877572> ?p ?o ?g. }
- W2068877572 endingPage "222" @default.
- W2068877572 startingPage "213" @default.
- W2068877572 abstract "The human brain has undergone rapid expansion since humans diverged from other great apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use cerebral organoids derived from human, gorilla, and chimpanzee cells to study developmental mechanisms driving evolutionary brain expansion. We find that neuroepithelial differentiation is a protracted process in apes, involving a previously unrecognized transition state characterized by a change in cell shape. Furthermore, we show that human organoids are larger due to a delay in this transition, associated with differences in interkinetic nuclear migration and cell cycle length. Comparative RNA sequencing (RNA-seq) reveals differences in expression dynamics of cell morphogenesis factors, including ZEB2, a known epithelial-mesenchymal transition regulator. We show that ZEB2 promotes neuroepithelial transition, and its manipulation and downstream signaling leads to acquisition of nonhuman ape architecture in the human context and vice versa, establishing an important role for neuroepithelial cell shape in human brain expansion." @default.
- W2068877572 created "2016-06-24" @default.
- W2068877572 creator A5036065071 @default.
- W2068877572 date "1976-03-01" @default.
- W2068877572 modified "2023-10-14" @default.
- W2068877572 title "Check-list of the data on the gestation length of primates" @default.
- W2068877572 cites W1608872557 @default.
- W2068877572 cites W1963609511 @default.
- W2068877572 cites W1963935268 @default.
- W2068877572 cites W1971972494 @default.
- W2068877572 cites W1972755704 @default.
- W2068877572 cites W1978181506 @default.
- W2068877572 cites W1982444723 @default.
- W2068877572 cites W1984569866 @default.
- W2068877572 cites W1986337854 @default.
- W2068877572 cites W1990304327 @default.
- W2068877572 cites W1993816448 @default.
- W2068877572 cites W1996761752 @default.
- W2068877572 cites W1997350782 @default.
- W2068877572 cites W2004027981 @default.
- W2068877572 cites W2005865564 @default.
- W2068877572 cites W2007858910 @default.
- W2068877572 cites W2010136846 @default.
- W2068877572 cites W2012555161 @default.
- W2068877572 cites W2015780509 @default.
- W2068877572 cites W2019353677 @default.
- W2068877572 cites W2019428614 @default.
- W2068877572 cites W2021600122 @default.
- W2068877572 cites W2022571080 @default.
- W2068877572 cites W2022835135 @default.
- W2068877572 cites W2024038399 @default.
- W2068877572 cites W2025392796 @default.
- W2068877572 cites W2029860477 @default.
- W2068877572 cites W2033482733 @default.
- W2068877572 cites W2033984947 @default.
- W2068877572 cites W2034579162 @default.
- W2068877572 cites W2035993424 @default.
- W2068877572 cites W2036980169 @default.
- W2068877572 cites W2038597116 @default.
- W2068877572 cites W2039320430 @default.
- W2068877572 cites W2040882216 @default.
- W2068877572 cites W2046759455 @default.
- W2068877572 cites W2048371486 @default.
- W2068877572 cites W2048394196 @default.
- W2068877572 cites W2052194425 @default.
- W2068877572 cites W2053217544 @default.
- W2068877572 cites W2055359422 @default.
- W2068877572 cites W2055613627 @default.
- W2068877572 cites W2055626748 @default.
- W2068877572 cites W2067642846 @default.
- W2068877572 cites W2068295237 @default.
- W2068877572 cites W2074559820 @default.
- W2068877572 cites W2075261993 @default.
- W2068877572 cites W2075745143 @default.
- W2068877572 cites W2078397462 @default.
- W2068877572 cites W2078590888 @default.
- W2068877572 cites W2079724862 @default.
- W2068877572 cites W2083284654 @default.
- W2068877572 cites W2086172923 @default.
- W2068877572 cites W2086427878 @default.
- W2068877572 cites W2090023790 @default.
- W2068877572 cites W2093831612 @default.
- W2068877572 cites W2096339940 @default.
- W2068877572 cites W2100638634 @default.
- W2068877572 cites W2113569445 @default.
- W2068877572 cites W2120033200 @default.
- W2068877572 cites W2122531730 @default.
- W2068877572 cites W2123814320 @default.
- W2068877572 cites W2158803323 @default.
- W2068877572 cites W2159831125 @default.
- W2068877572 cites W2172252967 @default.
- W2068877572 cites W2318020208 @default.
- W2068877572 cites W2319721635 @default.
- W2068877572 cites W2321969192 @default.
- W2068877572 cites W2326322418 @default.
- W2068877572 cites W2326456275 @default.
- W2068877572 cites W2413289594 @default.
- W2068877572 cites W4242447285 @default.
- W2068877572 cites W4244475450 @default.
- W2068877572 cites W4244771676 @default.
- W2068877572 cites W4245178808 @default.
- W2068877572 cites W4245959194 @default.
- W2068877572 cites W4253955445 @default.
- W2068877572 doi "https://doi.org/10.1016/0047-2484(76)90023-3" @default.
- W2068877572 hasPublicationYear "1976" @default.
- W2068877572 type Work @default.
- W2068877572 sameAs 2068877572 @default.
- W2068877572 citedByCount "38" @default.
- W2068877572 countsByYear W20688775722012 @default.
- W2068877572 countsByYear W20688775722017 @default.
- W2068877572 countsByYear W20688775722020 @default.
- W2068877572 countsByYear W20688775722021 @default.
- W2068877572 countsByYear W20688775722022 @default.
- W2068877572 crossrefType "journal-article" @default.
- W2068877572 hasAuthorship W2068877572A5036065071 @default.
- W2068877572 hasConcept C104317684 @default.
- W2068877572 hasConcept C136834591 @default.
- W2068877572 hasConcept C151730666 @default.