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• W2068884535 abstract "Clinical situations that require the use of systemic antibiotic therapy are common. Because millions of women choose oral contraceptives for birth control, the potential for interaction between these drugs frequently has to be considered. We review the available information and present a practical approach for dealing with this situation based on sharing responsibility with an educated patient.A 38-year-old woman with impetiginized eczema, who was treated with oral cefadroxil, 500 mg twice daily for 10 days, subsequently became pregnant and threatened the physicians who prescribed the antibiotic with a wrongful birth lawsuit because she was told that the antibiotic may have interfered with her low-estrogen oral contraceptives (OCs). Although it was proved that the women became pregnant 6-8 weeks after taking the cefadroxil, the physicians involved were inspired by this experience to research the literature on the interaction of antibiotics and oral contraceptives and to devise a practical approach for such situations. As a result of their data collection, they devised 3 categories of antibiotics ranging from those which likely reduce the effectiveness of OCs (rifampicin) to those which are associated with OC failure in 3 or more reported cases (ampicillin, amoxicillin, metronidazole, and tetracycline) to those which were associated with OC failure at least once (cephalexin, clindamycin, dapsone, erythromycin, griseofulvin, isoniazid, phenoxymethylpenicillin, telampicillin, and trimethoprim). The physicians recommended that a patient education hand-out include this information as well as directions to report any antibiotic associated diarrhea or breakthrough bleeding to the physician and a reminder to take OCs daily and that OCs are not perfect." @default.
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• W2068884535 date "1994-06-01" @default.
• W2068884535 modified "2023-10-18" @default.
• W2068884535 title "A practical approach to antibiotic treatment in women taking oral contraceptives" @default.
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• W2068884535 doi "https://doi.org/10.1016/s0190-9622(94)70127-x" @default.
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