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- W2068891486 abstract "Two vertebrate hypocholesterolemic agents (triparanol and 22,25-diazacholesterol) block the conversion of β-sitosterol to cholesterol in the larva of the tobacco hornworm, Manduca sexta (Johannson). A primary site of inhibitory action is the terminal step in this conversion—the reduction of desmosterol (24-dehydrocholesterol) to cholesterol. This is also the site at which these compounds inhibit de novo cholesterol biosynthesis in higher animals. Both agents severely inhibit growth and maturation of the tobacco hornworm." @default.
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- W2068891486 date "1967-06-23" @default.
- W2068891486 modified "2023-09-23" @default.
- W2068891486 title "Conversion of Beta Sitosterol to Cholesterol Blocked in an Insect by Hypocholesterolemic Agents" @default.
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- W2068891486 doi "https://doi.org/10.1126/science.156.3782.1637" @default.
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