FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068894003> ?p ?o ?g. }

• W2068894003 endingPage "7332" @default.
• W2068894003 startingPage "7327" @default.
• W2068894003 abstract "The calcium-activated phosphatase calcineurin is regulated by a binding cofactor known as modulatory calcineurin-interacting protein (MCIP) in yeast up through mammals. The physiologic function of MCIP remains an area of ongoing investigation, because both positive and negative calcineurin regulatory effects have been reported. Here we disrupted the mcip1 and mcip2 genes in the mouse and provide multiple lines of evidence that endogenous MCIP functions as a calcineurin facilitator in vivo. Mouse embryonic fibroblasts deficient in both mcip1/2 showed impaired activation of nuclear factor of activated T cells (NFAT), suggesting that MCIP is required for efficient calcineurin-NFAT coupling. Mice deficient in mcip1/2 showed a dramatic impairment in cardiac hypertrophy induced by pressure overload, neuroendocrine stimulation, or exercise, similar to mice lacking calcineurin Abeta. Moreover, simultaneous deletion of calcineurin Abeta in the mcip1/2-null background did not rescue impaired hypertrophic growth after pressure overload. Slow/oxidative fiber-type switching in skeletal muscle after exercise stimulation was also impaired in mcip1/2 mice, similar to calcineurin Abeta-null mice. Moreover, CD4(+) T cells from mcip1/2-null mice showed enhanced apoptosis that was further increased by loss of calcineurin Abeta. Finally, mcip1/2-null mice displayed a neurologic phenotype that was similar to calcineurin Abeta-null mice, such as increased locomotor activity and impaired working memory. Thus, a loss-of-function analysis suggests that MCIPs serve either a permissive or facilitative function for calcineurin-NFAT signaling in vivo." @default.
• W2068894003 created "2016-06-24" @default.
• W2068894003 creator A5000009332 @default.
• W2068894003 creator A5000358288 @default.
• W2068894003 creator A5010502668 @default.
• W2068894003 creator A5020999757 @default.
• W2068894003 creator A5032155254 @default.
• W2068894003 creator A5042556304 @default.
• W2068894003 creator A5056639915 @default.
• W2068894003 creator A5061534140 @default.
• W2068894003 creator A5075550603 @default.
• W2068894003 creator A5081835053 @default.
• W2068894003 creator A5082822397 @default.
• W2068894003 creator A5083678092 @default.
• W2068894003 date "2006-05-09" @default.
• W2068894003 modified "2023-10-16" @default.
• W2068894003 title "Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators <i>in vivo</i>" @default.
• W2068894003 cites W1897747135 @default.
• W2068894003 cites W1963956528 @default.
• W2068894003 cites W1964461613 @default.
• W2068894003 cites W1977316721 @default.
• W2068894003 cites W1991163286 @default.
• W2068894003 cites W1992967227 @default.
• W2068894003 cites W1998288502 @default.
• W2068894003 cites W1999383552 @default.
• W2068894003 cites W1999480270 @default.
• W2068894003 cites W2014223927 @default.
• W2068894003 cites W2020174502 @default.
• W2068894003 cites W2020955202 @default.
• W2068894003 cites W2025503860 @default.
• W2068894003 cites W2046958356 @default.
• W2068894003 cites W2052863274 @default.
• W2068894003 cites W2056597149 @default.
• W2068894003 cites W2060072866 @default.
• W2068894003 cites W2065023793 @default.
• W2068894003 cites W2066243964 @default.
• W2068894003 cites W2067319405 @default.
• W2068894003 cites W2067859370 @default.
• W2068894003 cites W2071267729 @default.
• W2068894003 cites W2073270614 @default.
• W2068894003 cites W2075479483 @default.
• W2068894003 cites W2075639377 @default.
• W2068894003 cites W2079004695 @default.
• W2068894003 cites W2084076332 @default.
• W2068894003 cites W2084347012 @default.
• W2068894003 cites W2085648653 @default.
• W2068894003 cites W2085968701 @default.
• W2068894003 cites W2094580473 @default.
• W2068894003 cites W2095758504 @default.
• W2068894003 cites W2102256305 @default.
• W2068894003 cites W2118325402 @default.
• W2068894003 cites W2123630494 @default.
• W2068894003 cites W2126373302 @default.
• W2068894003 cites W2130874431 @default.
• W2068894003 cites W2133386241 @default.
• W2068894003 cites W2135002082 @default.
• W2068894003 cites W2145303230 @default.
• W2068894003 cites W2145966324 @default.
• W2068894003 cites W2146456530 @default.
• W2068894003 cites W2146555288 @default.
• W2068894003 cites W2155483393 @default.
• W2068894003 cites W2156433522 @default.
• W2068894003 cites W2156504280 @default.
• W2068894003 cites W2156979262 @default.
• W2068894003 cites W2157973267 @default.
• W2068894003 cites W2167584205 @default.
• W2068894003 doi "https://doi.org/10.1073/pnas.0509340103" @default.
• W2068894003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1464340" @default.
• W2068894003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16648267" @default.
• W2068894003 hasPublicationYear "2006" @default.
• W2068894003 type Work @default.
• W2068894003 sameAs 2068894003 @default.
• W2068894003 citedByCount "119" @default.
• W2068894003 countsByYear W20688940032012 @default.
• W2068894003 countsByYear W20688940032013 @default.
• W2068894003 countsByYear W20688940032014 @default.
• W2068894003 countsByYear W20688940032015 @default.
• W2068894003 countsByYear W20688940032016 @default.
• W2068894003 countsByYear W20688940032017 @default.
• W2068894003 countsByYear W20688940032018 @default.
• W2068894003 countsByYear W20688940032020 @default.
• W2068894003 countsByYear W20688940032021 @default.
• W2068894003 countsByYear W20688940032022 @default.
• W2068894003 countsByYear W20688940032023 @default.
• W2068894003 crossrefType "journal-article" @default.
• W2068894003 hasAuthorship W2068894003A5000009332 @default.
• W2068894003 hasAuthorship W2068894003A5000358288 @default.
• W2068894003 hasAuthorship W2068894003A5010502668 @default.
• W2068894003 hasAuthorship W2068894003A5020999757 @default.
• W2068894003 hasAuthorship W2068894003A5032155254 @default.
• W2068894003 hasAuthorship W2068894003A5042556304 @default.
• W2068894003 hasAuthorship W2068894003A5056639915 @default.
• W2068894003 hasAuthorship W2068894003A5061534140 @default.
• W2068894003 hasAuthorship W2068894003A5075550603 @default.
• W2068894003 hasAuthorship W2068894003A5081835053 @default.
• W2068894003 hasAuthorship W2068894003A5082822397 @default.
• W2068894003 hasAuthorship W2068894003A5083678092 @default.
• W2068894003 hasBestOaLocation W20688940032 @default.

• next