Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068894787> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2068894787 endingPage "216" @default.
- W2068894787 startingPage "213" @default.
- W2068894787 abstract "To compare the sedative, anxiolytic, and amnestic effects, as well as the recovery characteristics, when midazolam (vs. a placebo) is administered to patients receiving a propofol infusion for sedation during local anesthesia.Randomized, double-blind, placebo-controlled study to evaluate the perioperative effects of intravenous (IV) midazolam.Outpatient surgery center of a university-affiliated medical center.One hundred thirty-nine consenting, ASA physical status I, II, and III outpatients undergoing elective surgical procedures under local anesthesia.Patients were randomly assigned to receive either midazolam 2 mg IV or saline 2 ml IV prior to injection of local anesthesia. Intraoperative sedation was maintained using a variable-rate propofol infusion.Preoperative assessment of sedation, anxiety, and amnesia was performed before and after IV midazolam. Intraoperative evaluations included level of sedation, as well as cardiovascular and respiratory measurements, at 1- to 5-minute intervals during the operation. Postoperatively, recovery of psychomotor function and patients' subjective feelings were assessed using the visual analog scale and questionnaires. Amnesia was assessed using picture recall during the perioperative period. In the operating room, midazolam 2 mg IV, compared with the placebo, produced a significantly greater increase in patients' level of sedation (7 +/- 13 mm to 49 +/- 21 mm for midazolam vs. 8 +/- 11 mm to 19 +/- 21 mm for the placebo; p less than 0.01) and a greater decrease in anxiety level (62 +/- 25 mm to 21 +/- 21 mm for midazolam vs. 54 +/- 27 mm to 53 +/- 22 mm for the placebo; p less than 0.01). Although the propofol dosage requirements to maintain comparable levels of sedation were similar in both groups, midazolam decreased patients' recall of intraoperative events (e.g., propofol-induced pain on injection and discomfort with local anesthetic injection) without significantly altering cardiorespiratory parameters or prolonging times to ambulation and discharge from the outpatient facility.Premedication with midazolam 2 mg IV produced increased sedation, amnesia, and anxiolysis when administered immediately prior to the propofol infusion as part of a sedation technique for outpatient surgery. This combination did not prolong the recovery room stay when compared with propofol alone." @default.
- W2068894787 created "2016-06-24" @default.
- W2068894787 creator A5026333279 @default.
- W2068894787 creator A5034429046 @default.
- W2068894787 creator A5079725992 @default.
- W2068894787 date "1992-05-01" @default.
- W2068894787 modified "2023-09-26" @default.
- W2068894787 title "Midazolam in combination with propofol for sedation during local anesthesia" @default.
- W2068894787 cites W1986931213 @default.
- W2068894787 cites W1992744837 @default.
- W2068894787 cites W2020512494 @default.
- W2068894787 cites W2062357169 @default.
- W2068894787 cites W2063857346 @default.
- W2068894787 cites W2077579315 @default.
- W2068894787 cites W2082366946 @default.
- W2068894787 cites W2094716164 @default.
- W2068894787 cites W2096266931 @default.
- W2068894787 cites W2168263144 @default.
- W2068894787 cites W2317713035 @default.
- W2068894787 doi "https://doi.org/10.1016/0952-8180(92)90068-c" @default.
- W2068894787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1610577" @default.
- W2068894787 hasPublicationYear "1992" @default.
- W2068894787 type Work @default.
- W2068894787 sameAs 2068894787 @default.
- W2068894787 citedByCount "86" @default.
- W2068894787 countsByYear W20688947872012 @default.
- W2068894787 countsByYear W20688947872013 @default.
- W2068894787 countsByYear W20688947872014 @default.
- W2068894787 countsByYear W20688947872015 @default.
- W2068894787 countsByYear W20688947872016 @default.
- W2068894787 countsByYear W20688947872017 @default.
- W2068894787 countsByYear W20688947872018 @default.
- W2068894787 countsByYear W20688947872019 @default.
- W2068894787 countsByYear W20688947872020 @default.
- W2068894787 countsByYear W20688947872021 @default.
- W2068894787 countsByYear W20688947872022 @default.
- W2068894787 crossrefType "journal-article" @default.
- W2068894787 hasAuthorship W2068894787A5026333279 @default.
- W2068894787 hasAuthorship W2068894787A5034429046 @default.
- W2068894787 hasAuthorship W2068894787A5079725992 @default.
- W2068894787 hasConcept C118552586 @default.
- W2068894787 hasConcept C142724271 @default.
- W2068894787 hasConcept C204787440 @default.
- W2068894787 hasConcept C27081682 @default.
- W2068894787 hasConcept C2776277131 @default.
- W2068894787 hasConcept C2776814716 @default.
- W2068894787 hasConcept C2777602617 @default.
- W2068894787 hasConcept C2778000748 @default.
- W2068894787 hasConcept C2778300832 @default.
- W2068894787 hasConcept C2778615406 @default.
- W2068894787 hasConcept C2780930544 @default.
- W2068894787 hasConcept C31174226 @default.
- W2068894787 hasConcept C42219234 @default.
- W2068894787 hasConcept C71924100 @default.
- W2068894787 hasConceptScore W2068894787C118552586 @default.
- W2068894787 hasConceptScore W2068894787C142724271 @default.
- W2068894787 hasConceptScore W2068894787C204787440 @default.
- W2068894787 hasConceptScore W2068894787C27081682 @default.
- W2068894787 hasConceptScore W2068894787C2776277131 @default.
- W2068894787 hasConceptScore W2068894787C2776814716 @default.
- W2068894787 hasConceptScore W2068894787C2777602617 @default.
- W2068894787 hasConceptScore W2068894787C2778000748 @default.
- W2068894787 hasConceptScore W2068894787C2778300832 @default.
- W2068894787 hasConceptScore W2068894787C2778615406 @default.
- W2068894787 hasConceptScore W2068894787C2780930544 @default.
- W2068894787 hasConceptScore W2068894787C31174226 @default.
- W2068894787 hasConceptScore W2068894787C42219234 @default.
- W2068894787 hasConceptScore W2068894787C71924100 @default.
- W2068894787 hasIssue "3" @default.
- W2068894787 hasLocation W20688947871 @default.
- W2068894787 hasLocation W20688947872 @default.
- W2068894787 hasOpenAccess W2068894787 @default.
- W2068894787 hasPrimaryLocation W20688947871 @default.
- W2068894787 hasRelatedWork W2001683931 @default.
- W2068894787 hasRelatedWork W2011221191 @default.
- W2068894787 hasRelatedWork W2077579315 @default.
- W2068894787 hasRelatedWork W2125749827 @default.
- W2068894787 hasRelatedWork W2130538431 @default.
- W2068894787 hasRelatedWork W2381437912 @default.
- W2068894787 hasRelatedWork W2400477220 @default.
- W2068894787 hasRelatedWork W2411528523 @default.
- W2068894787 hasRelatedWork W2519744167 @default.
- W2068894787 hasRelatedWork W2920816738 @default.
- W2068894787 hasVolume "4" @default.
- W2068894787 isParatext "false" @default.
- W2068894787 isRetracted "false" @default.
- W2068894787 magId "2068894787" @default.
- W2068894787 workType "article" @default.