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• W2068897625 abstract "High-content screening for small-molecule inducers of insulin expression identified the compound BRD7389, which caused alpha-cells to adopt several morphological and gene expression features of a beta-cell state. Assay-performance profile analysis suggests kinase inhibition as a mechanism of action, and we show that biochemical and cellular inhibition of the RSK kinase family by BRD7389 is likely related to its ability induce a beta-cell-like state. BRD7389 also increases the endocrine cell content and function of donor human pancreatic islets in culture." @default.
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• W2068897625 date "2010-08-09" @default.
• W2068897625 modified "2023-10-16" @default.
• W2068897625 title "Small-molecule inducers of insulin expression in pancreatic α-cells" @default.
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• W2068897625 doi "https://doi.org/10.1073/pnas.1010018107" @default.
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