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• W2068899455 abstract "Raf-1 kinase is a key regulator of a number of cellular processes, which promote the maintenance of a healthy colon epithelium. This study addresses the role of Raf in epithelial cell survival in response to dextran sulfate sodium (DSS)-induced injury and inflammation.Inducible intestinal epithelium-specific Raf knockout mice were generated and subjected to acute colitis followed by a short recovery period. Colon sections were analyzed by in situ oligo ligation or immunostaining for Ki67, phospho-extracellular signal regulated kinase, and nuclear factor-kappaB p65. Western blot analysis and terminal deoxynucleotidyl transferase nick-end labeling assays were performed on Raf small interfering RNA-transfected young adult mouse colon cells following DSS treatment.We report that Raf protects against epithelial injury and inflammation and promotes recovery from acute DSS-induced colitis by both MAPK/ERK kinase (MEK)-dependent and -independent pathways. Furthermore, we demonstrate that Raf induces novel cell survival responses through activating nuclear factor-kappaB in a MEK-independent manner.These novel findings indicate a protective role for Raf in colon epithelium following ulcerative damage through inhibiting cell apoptosis and promoting proliferation with important implications for responses such as inflammation-associated carcinogenesis." @default.
• W2068899455 created "2016-06-24" @default.
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• W2068899455 date "2008-08-01" @default.
• W2068899455 modified "2023-09-25" @default.
• W2068899455 title "Raf Protects Against Colitis by Promoting Mouse Colon Epithelial Cell Survival Through NF-κB" @default.
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• W2068899455 doi "https://doi.org/10.1053/j.gastro.2008.04.025" @default.
• W2068899455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2640938" @default.
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