Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068902486> ?p ?o ?g. }
- W2068902486 endingPage "3192" @default.
- W2068902486 startingPage "3186" @default.
- W2068902486 abstract "ABSTRACT Francisella tularensis , the etiological agent of tularemia, is found throughout the Northern hemisphere. After analyzing the F. tularensis genomic sequence for potential variable-number tandem repeats (VNTRs), we developed a multilocus VNTR analysis (MLVA) typing system for this pathogen. Variation was detected at six VNTR loci in a set of 56 isolates from California, Oklahoma, Arizona, and Oregon and the F. tularensis live vaccine strain. PCR assays revealed diversity at these loci with total allele numbers ranging from 2 to 20, and Nei's diversity index values ranging from 0.36 to 0.93. Cluster analysis identified two genetically distinct groups consistent with the current biovar classification system of F. tularensis . These findings suggest that these VNTR markers are useful for identifying F. tularensis isolates at this taxonomic level. In this study, biovar B isolates were less diverse than those in biovar A, possibly reflecting the history of tularemia in North America. Seven isolates from a recent epizootic in Maricopa County, Ariz., were identical at all VNTR marker loci. Their identity, even at a hypervariable VNTR locus, indicates a common source of infection. This demonstrates the applicability of MLVA for rapid characterization and identification of outbreak isolates. Future construction of reference databases will allow faster outbreak tracking as well as providing a foundation for deciphering global genetic relationships." @default.
- W2068902486 created "2016-06-24" @default.
- W2068902486 creator A5016832234 @default.
- W2068902486 creator A5045601734 @default.
- W2068902486 creator A5050592409 @default.
- W2068902486 creator A5070069241 @default.
- W2068902486 creator A5090399741 @default.
- W2068902486 creator A5090549211 @default.
- W2068902486 date "2001-09-01" @default.
- W2068902486 modified "2023-10-16" @default.
- W2068902486 title "<i>Francisella tularensis</i> Strain Typing Using Multiple-Locus, Variable-Number Tandem Repeat Analysis" @default.
- W2068902486 cites W15684062 @default.
- W2068902486 cites W1666247931 @default.
- W2068902486 cites W2000735518 @default.
- W2068902486 cites W2054993868 @default.
- W2068902486 cites W2101845860 @default.
- W2068902486 cites W2123546399 @default.
- W2068902486 cites W2134828511 @default.
- W2068902486 cites W2142730345 @default.
- W2068902486 cites W2143629111 @default.
- W2068902486 cites W2145004751 @default.
- W2068902486 cites W2145282362 @default.
- W2068902486 cites W2155551258 @default.
- W2068902486 doi "https://doi.org/10.1128/jcm.39.9.3186-3192.2001" @default.
- W2068902486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/88316" @default.
- W2068902486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11526148" @default.
- W2068902486 hasPublicationYear "2001" @default.
- W2068902486 type Work @default.
- W2068902486 sameAs 2068902486 @default.
- W2068902486 citedByCount "163" @default.
- W2068902486 countsByYear W20689024862012 @default.
- W2068902486 countsByYear W20689024862013 @default.
- W2068902486 countsByYear W20689024862014 @default.
- W2068902486 countsByYear W20689024862015 @default.
- W2068902486 countsByYear W20689024862016 @default.
- W2068902486 countsByYear W20689024862017 @default.
- W2068902486 countsByYear W20689024862018 @default.
- W2068902486 countsByYear W20689024862019 @default.
- W2068902486 countsByYear W20689024862020 @default.
- W2068902486 countsByYear W20689024862021 @default.
- W2068902486 countsByYear W20689024862022 @default.
- W2068902486 countsByYear W20689024862023 @default.
- W2068902486 crossrefType "journal-article" @default.
- W2068902486 hasAuthorship W2068902486A5016832234 @default.
- W2068902486 hasAuthorship W2068902486A5045601734 @default.
- W2068902486 hasAuthorship W2068902486A5050592409 @default.
- W2068902486 hasAuthorship W2068902486A5070069241 @default.
- W2068902486 hasAuthorship W2068902486A5090399741 @default.
- W2068902486 hasAuthorship W2068902486A5090549211 @default.
- W2068902486 hasBestOaLocation W20689024861 @default.
- W2068902486 hasConcept C104317684 @default.
- W2068902486 hasConcept C135763542 @default.
- W2068902486 hasConcept C159047783 @default.
- W2068902486 hasConcept C180754005 @default.
- W2068902486 hasConcept C189036908 @default.
- W2068902486 hasConcept C2775983634 @default.
- W2068902486 hasConcept C2778967756 @default.
- W2068902486 hasConcept C2780467176 @default.
- W2068902486 hasConcept C2781209916 @default.
- W2068902486 hasConcept C28245876 @default.
- W2068902486 hasConcept C54355233 @default.
- W2068902486 hasConcept C60987743 @default.
- W2068902486 hasConcept C61320498 @default.
- W2068902486 hasConcept C77434933 @default.
- W2068902486 hasConcept C84597430 @default.
- W2068902486 hasConcept C86803240 @default.
- W2068902486 hasConcept C93720030 @default.
- W2068902486 hasConceptScore W2068902486C104317684 @default.
- W2068902486 hasConceptScore W2068902486C135763542 @default.
- W2068902486 hasConceptScore W2068902486C159047783 @default.
- W2068902486 hasConceptScore W2068902486C180754005 @default.
- W2068902486 hasConceptScore W2068902486C189036908 @default.
- W2068902486 hasConceptScore W2068902486C2775983634 @default.
- W2068902486 hasConceptScore W2068902486C2778967756 @default.
- W2068902486 hasConceptScore W2068902486C2780467176 @default.
- W2068902486 hasConceptScore W2068902486C2781209916 @default.
- W2068902486 hasConceptScore W2068902486C28245876 @default.
- W2068902486 hasConceptScore W2068902486C54355233 @default.
- W2068902486 hasConceptScore W2068902486C60987743 @default.
- W2068902486 hasConceptScore W2068902486C61320498 @default.
- W2068902486 hasConceptScore W2068902486C77434933 @default.
- W2068902486 hasConceptScore W2068902486C84597430 @default.
- W2068902486 hasConceptScore W2068902486C86803240 @default.
- W2068902486 hasConceptScore W2068902486C93720030 @default.
- W2068902486 hasIssue "9" @default.
- W2068902486 hasLocation W20689024861 @default.
- W2068902486 hasLocation W20689024862 @default.
- W2068902486 hasLocation W20689024863 @default.
- W2068902486 hasOpenAccess W2068902486 @default.
- W2068902486 hasPrimaryLocation W20689024861 @default.
- W2068902486 hasRelatedWork W1488262302 @default.
- W2068902486 hasRelatedWork W2038586977 @default.
- W2068902486 hasRelatedWork W2057528483 @default.
- W2068902486 hasRelatedWork W2067867661 @default.
- W2068902486 hasRelatedWork W2068902486 @default.
- W2068902486 hasRelatedWork W2107386411 @default.
- W2068902486 hasRelatedWork W2890694369 @default.
- W2068902486 hasRelatedWork W3024464057 @default.