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• W2068903512 abstract "Like most phages with double-stranded DNA, phage T4 exits the infected host cell by a lytic process requiring, at a minimum, an endolysin and a holin. Unlike most phages, T4 can sense superinfection (which signals the depletion of uninfected host cells) and responds by delaying lysis and achieving an order-of-magnitude increase in burst size using a mechanism called lysis inhibition (LIN). T4 r mutants, which are unable to conduct LIN, produce distinctly large, sharp-edged plaques. The discovery of r mutants was key to the foundations of molecular biology, in particular to discovering and characterizing genetic recombination in T4, to redefining the nature of the gene, and to exploring the mutation process at the nucleotide level of resolution. A number of r genes have been described in the past 7 decades with various degrees of clarity. Here we describe an extensive and perhaps saturating search for T4 r genes and relate the corresponding mutational spectra to the often imperfectly known physiologies of the proteins encoded by these genes. Focusing on r genes whose mutant phenotypes are largely independent of the host cell, the genes are rI (which seems to sense superinfection and signal the holin to delay lysis), rIII (of poorly defined function), rIV (same as sp and also of poorly defined function), and rV (same as t, the holin gene). We did not identify any mutations that might correspond to a putative rVI gene, and we did not focus on the famous rII genes because they appear to affect lysis only indirectly." @default.
• W2068903512 created "2016-06-24" @default.
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• W2068903512 date "2011-05-13" @default.
• W2068903512 modified "2023-09-23" @default.
• W2068903512 title "The Bacteriophage T4 Rapid-Lysis Genes and Their Mutational Proclivities" @default.
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• W2068903512 doi "https://doi.org/10.1128/jb.00138-11" @default.
• W2068903512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3133318" @default.
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• W2068903512 hasPublicationYear "2011" @default.
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