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• W2068903911 abstract "Neuropeptide S (NPS) regulates various biological functions by activating the NPS receptor (NPSR). Previous studies demonstrated that the substitution of Gly(5) with d-amino acids generates NPSR antagonists. Eleven [d-Xaa(5)]NPS derivatives were synthesized and pharmacologically tested measuring [Ca(2+)](i) in HEK293(mNPSR) cells. The results confirmed that the [d-Xaa(5)] substitution promotes antagonist activity with potency inversely related to the side chain size and allowed identification of the novel potent NPSR peptide antagonist [(t)Bu-d-Gly(5)]NPS." @default.
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• W2068903911 date "2009-05-27" @default.
• W2068903911 modified "2023-10-18" @default.
• W2068903911 title "Further Studies at Neuropeptide S Position 5: Discovery of Novel Neuropeptide S Receptor Antagonists" @default.
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• W2068903911 doi "https://doi.org/10.1021/jm900604g" @default.
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